Acute early-life stress results in premature emergence of adult-like fear retention and extinction relapse in infant rats

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dc.contributor.authorCowan, Caitlin S. M.
dc.contributor.authorCallaghan, Bridget L.
dc.contributor.authorRichardson, Rick
dc.contributor.funderAustralian Research Councilen
dc.contributor.funderPetre Foundationen
dc.contributor.funderUniversity of New South Walesen
dc.date.accessioned2019-02-06T12:53:59Z
dc.date.available2019-02-06T12:53:59Z
dc.date.issued2013-10
dc.date.updated2019-02-05T16:26:35Z
dc.description.abstractRecent studies have shown that chronic early life stress results in precocious expression of the adult-like phenotype of fear retention and inhibition. However, it is unknown whether the experience of acute early trauma has the same effects as exposure to chronic early stress. In the present study, a 24-hr period of maternal deprivation on postnatal day (P) 9 was used as an acute early life stressor. In infancy (P16-17), maternally deprived and standard-reared rats were conditioned to fear a noise paired with shock. In Experiments 1 and 2, fear to the noise was then extinguished before rats were tested for context-mediated fear renewal or stress-induced fear reinstatement. In Experiments 3a and 3b, conditioned rats were tested for fear retention 1, 7, or 14 days after training. Whereas standard-reared infants exhibited relapse-resistant extinction and infantile amnesia (i.e., behaviors typical of their age), maternally deprived infants exhibited the renewal and reinstatement effects (i.e., relapse-prone extinction) and showed good retention of fear over the 7- and 14-day intervals (i.e., infantile amnesia was reduced). In other words, similar to rats exposed to chronic early life stress, rats exposed to acute early stress expressed an adult-like profile of fear retention and inhibition during infancy. These findings suggest that similar mechanisms might be involved in the effects of acute and chronic stress on emotional development, and may have implications for our understanding and treatment of emotional disorders associated with early adversity.en
dc.description.sponsorshipPetre Foundation (Petre Foundation Scholarship); University of New South Wales (UNSW Research Excellence Award)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCowan, C. S. M., Callaghan, B. L. and Richardson, R. (2013) 'Acute early-life stress results in premature emergence of adult-like fear retention and extinction relapse in infant rats', Behavioral Neuroscience, 127(5), pp. 703-711. doi:10.1037/a0034118en
dc.identifier.doi10.1037/a0034118
dc.identifier.endpage711en
dc.identifier.issn1939-0084
dc.identifier.issued5en
dc.identifier.journaltitleBehavioral Neuroscienceen
dc.identifier.startpage703en
dc.identifier.urihttps://hdl.handle.net/10468/7450
dc.identifier.volume127en
dc.language.isoenen
dc.publisherAmerican Psychological Associationen
dc.relation.projectinfo:eu-repo/grantAgreement/ARC/Discovery Projects/DP0985554/AU/Developmental analysis of extinction of learned fear in rats/en
dc.relation.projectinfo:eu-repo/grantAgreement/ARC/Discovery Projects/DP120104925/AU/Effects of early life trauma on fear memory and fear extinction in rats/en
dc.relation.urihttp://dx.doi.org/10.1037/a0034118
dc.rights© American Psychological Association, 2013. This paper is not the copy of record and may not exactly replicate the authoritative document published in the APA journal. Please do not copy or cite without author's permission. The final article is available, upon publication, at: http://dx.doi.org/10.1037/a0034118en
dc.subjectMaternal deprivationen
dc.subjectStress, psychologicalen
dc.subjectSeparation MSen
dc.subjectDevelopmenten
dc.subjectExtinctionen
dc.subjectFear conditioningen
dc.subjectInfantile amnesiaen
dc.subjectMaternal deprivationen
dc.titleAcute early-life stress results in premature emergence of adult-like fear retention and extinction relapse in infant ratsen
dc.typeArticle (peer-reviewed)en
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