Contourlet textual features: improving the diagnosis of solitary pulmonary nodules in two dimensional CT images

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dc.contributor.authorWang, Jingjing
dc.contributor.authorSun, Tao
dc.contributor.authorGao, Ni
dc.contributor.authorMenon, Desmond Dev
dc.contributor.authorLuo, Yanxia
dc.contributor.authorGao, Qi
dc.contributor.authorLi, Xia
dc.contributor.authorWang, Wei
dc.contributor.authorZhu, Huiping
dc.contributor.authorLv, Pingxin
dc.contributor.authorLiang, Zhigang
dc.contributor.authorTao, Lixin
dc.contributor.authorLiu, Xiangtong
dc.contributor.authorGuo, Xiuhua
dc.contributor.funderNational Natural Science Foundation of China
dc.contributor.funderBeijing Municipal Natural Science Foundation
dc.date.accessioned2016-02-17T11:43:38Z
dc.date.available2016-02-17T11:43:38Z
dc.date.issued2014
dc.description.abstractObjective: To determine the value of contourlet textural features obtained from solitary pulmonary nodules in two dimensional CT images used in diagnoses of lung cancer. Materials and Methods: A total of 6,299 CT images were acquired from 336 patients, with 1,454 benign pulmonary nodule images from 84 patients (50 male, 34 female) and 4,845 malignant from 252 patients (150 male, 102 female). Further to this, nineteen patient information categories, which included seven demographic parameters and twelve morphological features, were also collected. A contourlet was used to extract fourteen types of textural features. These were then used to establish three support vector machine models. One comprised a database constructed of nineteen collected patient information categories, another included contourlet textural features and the third one contained both sets of information. Ten-fold cross-validation was used to evaluate the diagnosis results for the three databases, with sensitivity, specificity, accuracy, the area under the curve (AUC), precision, Youden index, and F-measure were used as the assessment criteria. In addition, the synthetic minority over-sampling technique (SMOTE) was used to preprocess the unbalanced data. Results: Using a database containing textural features and patient information, sensitivity, specificity, accuracy, AUC, precision, Youden index, and F-measure were: 0.95, 0.71, 0.89, 0.89, 0.92, 0.66, and 0.93 respectively. These results were higher than results derived using the database without textural features (0.82, 0.47, 0.74, 0.67, 0.84, 0.29, and 0.83 respectively) as well as the database comprising only textural features (0.81, 0.64, 0.67, 0.72, 0.88, 0.44, and 0.85 respectively). Using the SMOTE as a pre-processing procedure, new balanced database generated, including observations of 5,816 benign ROIs and 5,815 malignant ROIs, and accuracy was 0.93. Conclusion: Our results indicate that the combined contourlet textural features of solitary pulmonary nodules in CT images with patient profile information could potentially improve the diagnosis of lung cancer.en
dc.description.sponsorshipNational Natural Science Foundation of China (81172772); Beijing Municipal Natural Science Foundation, China (4112015, 7131002)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide108465
dc.identifier.citationWang J, Sun T, Gao N, Menon DD, Luo Y, Gao Q, et al. (2014) Contourlet Textual Features: Improving the Diagnosis of Solitary Pulmonary Nodules in Two Dimensional CT Images. PLoS ONE 9(9): e108465. doi:10.1371/journal.pone.0108465
dc.identifier.doi10.1371/journal.pone.0108465
dc.identifier.issn1932-6203
dc.identifier.issued9en
dc.identifier.journaltitlePLOS ONEen
dc.identifier.urihttps://hdl.handle.net/10468/2325
dc.identifier.volume9en
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.rights© 2015 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are crediteden
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectSupport vector machineen
dc.subjectComputer-aided diagnosisen
dc.subjectLung canceren
dc.subjectTomographyen
dc.subjectCurveleten
dc.subjectProbabilityen
dc.subjectPerformanceen
dc.subjectTransformen
dc.subjectWaveleten
dc.subjectSchemeen
dc.titleContourlet textual features: improving the diagnosis of solitary pulmonary nodules in two dimensional CT imagesen
dc.typeArticle (peer-reviewed)en
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