Nonrandomized studies of interventions - complementary or just convenient?

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dc.check.date2026-07-18en
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisheren
dc.contributor.authorDahly, Darren L.en
dc.contributor.authorWilkinson, Jacken
dc.date.accessioned2025-09-12T13:27:34Z
dc.date.available2025-09-12T13:27:34Z
dc.date.issued2025-07-18en
dc.descriptionRefers to: Schwarze, J. E., Tennant, P. W., Barnhart, K., Platt, R. W., Gupta, S., Venetis, C., D'Hooghe, T. and Schisterman, E.F. (2025) 'Recommendation to improve the rigor and impact of non-randomized studies of interventions in fertility treatment research', Fertility and Sterility. https://doi.org/10.1016/j.fertnstert.2025.05.168en
dc.description.abstractSchwarze et al. present recommendations to improve the quality of nonrandomized studies of interventions (NRSIs). Given the methodological errors we regularly encounter when reading and reviewing NRSIs in assisted reproductive technologies (ART), we support the need for such recommendations to help researchers better design, analyze, and interpret these studies. That said, we are concerned that those who require such guidance will, almost by definition, not understand when the use of NRSIs is warranted, or mistake them as viable alternatives to randomized controlled trials (RCTs), despite reassurances from Schwarze et al. that NRSIs should be viewed as complementary. Our concerns are particularly relevant for ART, where regulation is limited, commercial conflicts of interest are common, and interventions are regularly adopted before they are evaluated using RCTs. To be clear, we do not see these as points of disagreement with Schwarze et al., but rather as additional points for consideration.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationDahly, D. L. and Wilkinson, J. (2025) 'Nonrandomized studies of interventions - complementary or just convenient?', Fertility and Sterility. https://doi.org/10.1016/j.fertnstert.2025.07.019en
dc.identifier.doi10.1016/j.fertnstert.2025.07.019en
dc.identifier.issn0015-0282en
dc.identifier.journaltitleFertility and Sterilityen
dc.identifier.urihttps://hdl.handle.net/10468/17867
dc.language.isoenen
dc.publisherElsevier Ltd.en
dc.relation.ispartofFertility and Sterilityen
dc.rights© 2025, American Society for Reproductive Medicine. Published by Elsevier Inc. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectNonrandomized studies of interventions (NRSIs)en
dc.subjectAssisted reproductive technologies (ART)en
dc.subjectRandomized controlled trials (RCTs)en
dc.titleNonrandomized studies of interventions - complementary or just convenient?en
dc.typeArticle (peer-reviewed)en
dc.typejournal-articleen
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