The impact of western diet and nutrients on the microbiota and immune response at mucosal interfaces

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dc.contributor.authorStatovci, Donjete
dc.contributor.authorAguilera, Monica
dc.contributor.authorMacSharry, John
dc.contributor.authorMelgar, Silvia
dc.contributor.funderScience Foundation Ireland
dc.date.accessioned2017-09-26T11:39:20Z
dc.date.available2017-09-26T11:39:20Z
dc.date.issued2017
dc.description.abstractRecent findings point toward diet having a major impact on human health. Diets can either affect the gut microbiota resulting in alterations in the host's physiological responses or by directly targeting the host response. The microbial community in the mammalian gut is a complex and dynamic system crucial for the development and maturation of both systemic and mucosal immune responses. Therefore, the complex interaction between available nutrients, the microbiota, and the immune system are central regulators in maintaining homeostasis and fighting against invading pathogens at mucosal sites. Westernized diet, defined as high dietary intake of saturated fats and sucrose and low intake of fiber, represent a growing health risk contributing to the increased occurrence of metabolic diseases, e.g., diabetes and obesity in countries adapting a westernized lifestyle. Inflammatory bowel diseases (IBD) and asthma are chronic mucosal inflammatory conditions of unknown etiology with increasing prevalence worldwide. These conditions have a multifactorial etiology including genetic factors, environmental factors, and dysregulated immune responses. Their increased prevalence cannot solely be attributed to genetic considerations implying that other factors such as diet can be a major contributor. Recent reports indicate that the gut microbiota and modifications thereof, due to a consumption of a diet high in saturated fats and low in fibers, can trigger factors regulating the development and/or progression of both conditions. While asthma is a disease of the airways, increasing evidence indicates a link between the gut and airways in disease development. Herein, we provide a comprehensive review on the impact of westernized diet and associated nutrients on immune cell responses and the microbiota and how these can influence the pathology of IBD and asthma.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid838
dc.identifier.citationStatovci, D., Aguilera, M., MacSharry, J. and Melgar, S. (2017) 'The impact of western diet and nutrients on the microbiota and immune response at mucosal interfaces', Frontiers in Immunology, 8, 838 (21pp). doi: 10.3389/fimmu.2017.00838en
dc.identifier.doi10.3389/fimmu.2017.00838
dc.identifier.issn1664-3224
dc.identifier.journaltitleFrontiers in Immunologyen
dc.identifier.urihttps://hdl.handle.net/10468/4797
dc.identifier.volume8
dc.language.isoenen
dc.publisherFrontiers Media S.A.en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/
dc.relation.urihttp://journal.frontiersin.org/article/10.3389/fimmu.2017.00838/full
dc.rights© 2017, Statovci, Aguilera, MacSharry and Melgar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectWesternized dieten
dc.subjectInflammatory bowel diseaseen
dc.subjectAsthmaen
dc.subjectSaturated faten
dc.subjectMicronutrientsen
dc.subjectMicrobiotaen
dc.subjectInflammatory bowel diseaseen
dc.subjectPolyunsaturated fatty acidsen
dc.subjectInnate lymphoid cellsen
dc.subjectVitamin D receptoren
dc.subjectMesenteric adipose tissueen
dc.subjectSodium induced colitisen
dc.subjectPiama birth cohorten
dc.subjectRegulatory t cellsen
dc.subjectCrohns diseaseen
dc.subjectUlcerative colitisen
dc.titleThe impact of western diet and nutrients on the microbiota and immune response at mucosal interfacesen
dc.typeArticle (peer-reviewed)en
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