Low-molecular-weight seaweed-derived polysaccharides lead to increased faecal bulk but do not alter human gut health markers

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dc.contributor.authorBannon, Ciara D.
dc.contributor.authorEckenberger, Julia
dc.contributor.authorSnelling, William J.
dc.contributor.authorHuseyin, Chloe E.
dc.contributor.authorAllsopp, Philip J.
dc.contributor.authorStrain, Conall R.
dc.contributor.authorRamnani, Priya
dc.contributor.authorChitarrari, Roberto
dc.contributor.authorGrant, John
dc.contributor.authorHotchkiss, Sarah
dc.contributor.authorPhilp, Kevin
dc.contributor.authorCampbell, Ross
dc.contributor.authorTuohy, Kieran M.
dc.contributor.authorClaesson, Marcus J.
dc.contributor.authorTernan, Nigel George
dc.contributor.authorDooley, James S. G.
dc.contributor.authorSleator, Roy D.
dc.contributor.authorRowland, Ian
dc.contributor.authorGill, Chris I. R.
dc.contributor.funderSeventh Framework Programmeen
dc.date.accessioned2022-11-09T15:20:55Z
dc.date.available2022-11-09T15:20:55Z
dc.date.issued2021-12
dc.date.updated2022-11-09T14:42:41Z
dc.description.abstractSeaweeds are potentially sustainable crops and are receiving significant interest because of their rich bioactive compound content; including fatty acids, polyphenols, carotenoids, and complex polysaccharides. However, there is little information on the in vivo effects on gut health of the polysaccharides and their low-molecular-weight derivatives. Herein, we describe the first investigation into the prebiotic potential of low-molecular-weight polysaccharides (LMWPs) derived from alginate and agar in order to validate their in vivo efficacy. We conducted a randomized; placebo-controlled trial testing the impact of alginate and agar LWMPs on faecal weight and other markers of gut health and on composition of gut microbiota. We show that these LMWPs led to significantly increased faecal bulk (20-30%). Analysis of gut microbiome composition by sequencing indicated no significant changes attributable to treatment at the phylum and family level, although FISH analysis showed an increase in Faecalibacterium prausnitzii in subjects consuming agar LMWP. Sequence analysis of gut bacteria corroborated with the FISH data, indicating that alginate and agar LWMPs do not alter human gut microbiome health markers. Crucially, our findings suggest an urgent need for robust and rigorous human in vivo testing-in particular, using refined seaweed extracts.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBannon, C. D., Eckenberger, J., Snelling, W. J., Huseyin, C. E., Allsopp, P. J., Strain, C. R., Ramnani, P., Chitarrari, R., Grant, J., Hotchkiss, S., Philp, K., Campbell, R., Tuohy, K. M., Claesson, M, J., Ternan, N. G., Dooley, J. S. G.; Sleator, R. D., Rowland, I. and Gill, C. I. R. (2021) 'Low-molecular-weight seaweed-derived polysaccharides lead to increased faecal bulk but do not alter human gut health markers', Foods, 10 (12), (18pp). doi: 10.3390/foods10122988en
dc.identifier.doi10.3390/foods10122988en
dc.identifier.endpage16en
dc.identifier.issn2304-8158
dc.identifier.issued12en
dc.identifier.journaltitleFoodsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/13843
dc.identifier.volume10en
dc.language.isoenen
dc.publisherMDPIen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP4::SME/222470/EU/Hydrocolloids as functional food ingredients for gut health/HYFFIen
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectFaecal bulken
dc.subjectSeaweeden
dc.subjectBacteriomeen
dc.subjectHealth benefitsen
dc.titleLow-molecular-weight seaweed-derived polysaccharides lead to increased faecal bulk but do not alter human gut health markersen
dc.typeArticle (peer-reviewed)en
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