Human milk oligosaccharides: shaping the infant gut microbiota and supporting health

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dc.contributor.authorWalsh, Clodagh
dc.contributor.authorLane, Jonathan A.
dc.contributor.authorvan Sinderen, Douwe
dc.contributor.authorHickey, Rita M.
dc.contributor.funderH and H Group
dc.contributor.funderScience Foundation Ireland
dc.date.accessioned2023-11-07T14:57:54Z
dc.date.available2023-11-07T14:43:54Zen
dc.date.available2023-11-07T14:57:54Z
dc.date.issued2020-09en
dc.date.updated2023-11-07T14:43:57Zen
dc.description.abstractHuman milk oligosaccharides (HMO) are complex sugars which are found in breast milk at significant concentrations and with unique structural diversity. These sugars are the fourth most abundant component of human milk after water, lipids, and lactose and yet provide no direct nutritional value to the infant. Recent research has highlighted that HMOs have various functional roles to play in infant development. These sugars act as prebiotics by promoting growth of beneficial intestinal bacteria thereby generating short-chain fatty acids which are critical for gut health. HMOs also directly modulate host-epithelial immune responses and can selectively reduce binding of pathogenic bacteria and viruses to the gut epithelium preventing the emergence of a disease. This review covers current knowledge related to the functional biology of HMOs and their associated impact on infant gut health.
dc.description.statusPeer revieweden
dc.description.versionPublished Version
dc.format.mimetypeapplication/pdf
dc.identifier.articleid104074
dc.identifier.citationWalsh, C., Lane, J.A., Van Sinderen, D. and Hickey, R.M. (2020) ‘Human milk oligosaccharides: Shaping the infant gut microbiota and supporting health’, Journal of Functional Foods, 72, 104074 (13pp). doi: 10.1016/j.jff.2020.104074
dc.identifier.doi10.1016/j.jff.2020.104074en
dc.identifier.endpage13
dc.identifier.issn1756-4646
dc.identifier.journaltitleJournal of Functional Foods
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/15199
dc.identifier.volume72
dc.language.isoenen
dc.publisherElsevier
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/
dc.rights© 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBreast milk
dc.subjectGut health
dc.subjectHuman milk oligosaccharides
dc.subjectPrebiotics
dc.titleHuman milk oligosaccharides: shaping the infant gut microbiota and supporting health
dc.typeArticle (peer-reviewed)
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