A core outcome set for studies of gestational diabetes mellitus prevention and treatment

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dc.contributor.authorEgan, Aoife M.
dc.contributor.authorBogdanet, Delia
dc.contributor.authorGriffin, Tomás P.
dc.contributor.authorKgosidialwa, O.
dc.contributor.authorCervar-Zivkovic, Mila
dc.contributor.authorDempsey, Eugene M.
dc.contributor.authorAllotey, John
dc.contributor.authorAlvarado, Fernanda
dc.contributor.authorClarson, Cheril
dc.contributor.authorCooray, Shamil D.
dc.contributor.authorde Valk, Harold W.
dc.contributor.authorGaljaard, Sander
dc.contributor.authorLoeken, Mary R.
dc.contributor.authorMaresh, Michael
dc.contributor.authorNapoli, Angela
dc.contributor.authorO'Shea, Paula M.
dc.contributor.authorWender-Ozegowska, Ewa
dc.contributor.authorvan Poppel, Mireille N. M.
dc.contributor.authorThangaratinam, Shakila
dc.contributor.authorCrowther, Caroline
dc.contributor.authorBiesty, Linda M.
dc.contributor.authorDevane, Declan
dc.contributor.authorDunne, Fidelma P.
dc.date.accessioned2022-06-09T15:10:54Z
dc.date.available2022-06-09T15:10:54Z
dc.date.issued2020-03
dc.date.updated2022-06-09T14:48:21Z
dc.description.abstractAims/hypothesis: The aim of this systematic review was to develop core outcome sets (COSs) for trials evaluating interventions for the prevention or treatment of gestational diabetes mellitus (GDM). Methods: We identified previously reported outcomes through a systematic review of the literature. These outcomes were presented to key stakeholders (including patient representatives, researchers and clinicians) for prioritisation using a three-round, e-Delphi study. A priori consensus criteria informed which outcomes were brought forward for discussion at a face-to-face consensus meeting where the COS was finalised. Results: Our review identified 74 GDM prevention and 116 GDM treatment outcomes, which were presented to stakeholders in round 1 of the e-Delphi study. Round 1 was completed by 173 stakeholders, 70% (121/173) of whom went on to complete round 2; 84% (102/121) of round 2 responders completed round 3. Twenty-two GDM prevention outcomes and 30 GDM treatment outcomes were discussed at the consensus meeting. Owing to significant overlap between included prevention and treatment outcomes, consensus meeting stakeholders agreed to develop a single prevention/treatment COS. Fourteen outcomes were included in the final COS. These consisted of six maternal outcomes (GDM diagnosis, adherence to the intervention, hypertensive disorders of pregnancy, requirement and type of pharmacological therapy for hyperglycaemia, gestational weight gain and mode of birth) and eight neonatal outcomes (birthweight, large for gestational age, small for gestational age, gestational age at birth, preterm birth, neonatal hypoglycaemia, neonatal death and stillbirth). Conclusions/interpretation: This COS will enable future GDM prevention and treatment trials to measure similar outcomes that matter to stakeholders and facilitate comparison and combination of these studies.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationEgan, A. M., Bogdanet, D., Griffin, T. P., Kgosidialwa, O., Cervar-Zivkovic, M., Dempsey, E. M., Allotey, J., Alvarado, F., Clarson, C., Cooray, S. D., de Valk, H. W., Galjaard, S., Loeken, M. R., Maresh, M., Napoli, A., O'Shea, P. M., Wender-Ozegowska, E., van Poppel, M. N. M., Thangaratinam, S., Crowther, C., Biesty, L. M., Devane, D. and Dunne, F. P. (2020) 'A core outcome set for studies of gestational diabetes mellitus prevention and treatment', Diabetologia, 63 (6), pp. 1120-1127. doi: 10.1007/s00125-020-05123-6en
dc.identifier.doi10.1007/s00125-020-05123-6en
dc.identifier.endpage1127en
dc.identifier.issn0012-186X
dc.identifier.issued6en
dc.identifier.journaltitleDiabetologiaen
dc.identifier.startpage1120en
dc.identifier.urihttps://hdl.handle.net/10468/13292
dc.identifier.volume63en
dc.language.isoenen
dc.publisherSpringeren
dc.rights©The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/.en
dc.subjectClinical diabetesen
dc.subjectCore outcome seten
dc.subjectInsulin therapyen
dc.subjectPregnancyen
dc.subjectSystematic reviewen
dc.titleA core outcome set for studies of gestational diabetes mellitus prevention and treatmenten
dc.typeArticle (peer-reviewed)en
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