Localized partitioning of enantiomers in solid samples of sulfoxides: importance of sampling method in determination of enantiopurity

Flynn, Aaran J.; Ford, Alan; Maguire, Anita R.

Localized partitioning of enantiomers in solid samples of sulfoxides: importance of sampling method in determination of enantiopurity

dc.contributor.author	Flynn, Aaran J.
dc.contributor.author	Ford, Alan
dc.contributor.author	Maguire, Anita R.
dc.date.accessioned	2020-09-17T10:57:33Z
dc.date.available	2020-09-17T10:57:33Z
dc.date.issued	2020-07-02
dc.date.updated	2020-09-17T10:47:03Z
dc.description.abstract	Localized partitioning of amorphous enantioenriched aryl benzyl sulfoxides in the solid state can lead to substantial variation in enantiopurities, even for sulfoxides which do not show detectable levels of self-disproportionation of enantiomers (SDE) during chromatography on an achiral stationary phase. The importance of preparation of representative samples of enantioenriched sulfoxides for chiral HPLC to enable reproducible results is clear.	en
dc.description.status	Peer reviewed	en
dc.description.version	Accepted Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Flynn, A. J., Ford, A. and Maguire, A. R. (2020) 'Localized Partitioning of Enantiomers in Solid Samples of Sulfoxides: Importance of Sampling Method in Determination of Enantiopurity', The Journal of Organic Chemistry, 85(15), pp. 10216-10221. doi: 10.1021/acs.joc.0c01094	en
dc.identifier.doi	10.1021/acs.joc.0c01094	en
dc.identifier.endpage	10221	en
dc.identifier.issn	0022-3263
dc.identifier.journaltitle	The Journal of Organic Chemistry	en
dc.identifier.startpage	10216	en
dc.identifier.uri	https://hdl.handle.net/10468/10542
dc.identifier.volume	85	en
dc.language.iso	en	en
dc.publisher	American Chemical Society	en
dc.relation.uri	https://pubs.acs.org/doi/10.1021/acs.joc.0c01094
dc.rights	© 2020 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Organic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.joc.0c01094	en
dc.subject	Efficient asymmetric oxidation	en
dc.subject	Self-disproportionation	en
dc.subject	Chiral sulfoxides	en
dc.subject	Chromatography	en
dc.subject	Sulfides	en
dc.subject	Ligands	en
dc.subject	Sde	en
dc.subject	Importance sampling	en
dc.subject	Enantiomers	en
dc.subject	Chiral HPLC	en
dc.subject	Disproportionations	en
dc.subject	Enantiopurity	en
dc.subject	Representative sample	en
dc.subject	Sampling method	en
dc.subject	Solid samples	en
dc.subject	Stationary phase	en
dc.subject	Substantial variations	en
dc.title	Localized partitioning of enantiomers in solid samples of sulfoxides: importance of sampling method in determination of enantiopurity	en
dc.type	Article (peer-reviewed)	en