Localized partitioning of enantiomers in solid samples of sulfoxides: importance of sampling method in determination of enantiopurity

dc.contributor.authorFlynn, Aaran J.
dc.contributor.authorFord, Alan
dc.contributor.authorMaguire, Anita R.
dc.date.accessioned2020-09-17T10:57:33Z
dc.date.available2020-09-17T10:57:33Z
dc.date.issued2020-07-02
dc.date.updated2020-09-17T10:47:03Z
dc.description.abstractLocalized partitioning of amorphous enantioenriched aryl benzyl sulfoxides in the solid state can lead to substantial variation in enantiopurities, even for sulfoxides which do not show detectable levels of self-disproportionation of enantiomers (SDE) during chromatography on an achiral stationary phase. The importance of preparation of representative samples of enantioenriched sulfoxides for chiral HPLC to enable reproducible results is clear.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationFlynn, A. J., Ford, A. and Maguire, A. R. (2020) 'Localized Partitioning of Enantiomers in Solid Samples of Sulfoxides: Importance of Sampling Method in Determination of Enantiopurity', The Journal of Organic Chemistry, 85(15), pp. 10216-10221. doi: 10.1021/acs.joc.0c01094en
dc.identifier.doi10.1021/acs.joc.0c01094en
dc.identifier.endpage10221en
dc.identifier.issn0022-3263
dc.identifier.journaltitleThe Journal of Organic Chemistryen
dc.identifier.startpage10216en
dc.identifier.urihttps://hdl.handle.net/10468/10542
dc.identifier.volume85en
dc.language.isoenen
dc.publisherAmerican Chemical Societyen
dc.relation.urihttps://pubs.acs.org/doi/10.1021/acs.joc.0c01094
dc.rights© 2020 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Organic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.joc.0c01094en
dc.subjectEfficient asymmetric oxidationen
dc.subjectSelf-disproportionationen
dc.subjectChiral sulfoxidesen
dc.subjectChromatographyen
dc.subjectSulfidesen
dc.subjectLigandsen
dc.subjectSdeen
dc.subjectImportance samplingen
dc.subjectEnantiomersen
dc.subjectChiral HPLCen
dc.subjectDisproportionationsen
dc.subjectEnantiopurityen
dc.subjectRepresentative sampleen
dc.subjectSampling methoden
dc.subjectSolid samplesen
dc.subjectStationary phaseen
dc.subjectSubstantial variationsen
dc.titleLocalized partitioning of enantiomers in solid samples of sulfoxides: importance of sampling method in determination of enantiopurityen
dc.typeArticle (peer-reviewed)en
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