The gut microbiota alone and in combination with a social stimulus regulates cocaine reward in the mouse

Simple item page
dc.contributor.authorGarcía-Cabrerizo, Rubénen
dc.contributor.authorBarros-Santos, Thaísaen
dc.contributor.authorCampos, Daviden
dc.contributor.authorCryan, John F.en
dc.contributor.funderHorizon 2020en
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2023-06-14T11:56:55Z
dc.date.available2023-06-14T11:56:55Z
dc.date.issued2022-11-02en
dc.description.abstractThe gut microbiota is a key factor in the maintenance of physiological homeostasis and immunity. Correlational studies have demonstrated that alterations in microbiota composition have been associated with addiction. Moreover, animal studies have confirmed a link between reward and social processes, which may be shaped by the gut microbiota thus influencing neurodevelopment and the programming of social behaviors across diverse animal species. However, whether there is an interaction between the microbiota and social reward processes in the context of drug reward remains unclear. To this end, we explored the influence of gut microbiota in regulating behaviourally conditioned responses to different rewards (cocaine and social interactions). Depletion of the intestinal microbiota resulted in differential reward responses to both drug and social stimuli with an attenuation of the former and enhancement of the latter independent of concomitant immune changes. Moreover, the combination of depleting the gut microbiota in the presence of a positive social stimulus attenuates cocaine reward. Together these data suggest that the two-pronged approach of targeting the microbiota and enhancing social behaviour could constitute a valuable component in reducing harm in drug use by altering the salient effects of cocaine.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationGarcía-Cabrerizo, R., Barros-Santos, T., Campos, D. and Cryan, J. F. (2023) 'The gut microbiota alone and in combination with a social stimulus regulates cocaine reward in the mouse', Brain, Behavior, and Immunity, 107, pp. 286-291. doi: 10.1016/j.bbi.2022.10.020en
dc.identifier.doi10.1016/j.bbi.2022.10.020en
dc.identifier.endpage291en
dc.identifier.issn0889-1591en
dc.identifier.journaltitleBrain, Behavior, and Immunityen
dc.identifier.startpage286en
dc.identifier.urihttps://hdl.handle.net/10468/14582
dc.identifier.volume107en
dc.language.isoenen
dc.publisherElsevier B.V.en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/754535/EU/APC Postdoctoral EXcellence Programme/APEXen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres Programme::Phase 2/12/RC/2273_P2/IE/APC_Phase 2/en
dc.rights© 2022, the Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectAntibioticsen
dc.subjectDrug addictionen
dc.subjectMicrobiotaen
dc.subjectRewarden
dc.subjectSocial behavioren
dc.titleThe gut microbiota alone and in combination with a social stimulus regulates cocaine reward in the mouseen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1-s2.0-S0889159122004251-main.pdf
Size:
1.62 MB
Format:
Adobe Portable Document Format
Description:
Published Version
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
APC Microbiome Ireland - Journal Articles
Anatomy and Neuroscience - Journal Articles