Impact of glyphosate (RoundupTM) on the composition and functionality of the gut microbiome

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dc.contributor.authorWalsh, Laurenen
dc.contributor.authorHill, Colinen
dc.contributor.authorRoss, R. Paulen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderEuropean Commissionen
dc.contributor.funderEuropean Research Councilen
dc.date.accessioned2024-03-13T13:04:20Z
dc.date.available2024-03-13T13:04:20Z
dc.date.issued2023en
dc.description.abstractGlyphosate, the active ingredient in the broad-spectrum herbicide RoundupTM, has been a topic of discussion for decades due to contradictory reports of the effect of glyphosate on human health. Glyphosate inhibits the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) of the shikimic pathway producing aromatic amino acids in plants, a mechanism that suggests that the herbicide would not affect humans as this pathway is not found in mammals. However, numerous studies have implicated glyphosate exposure in the manifestation of a variety of disorders in the human body. This review specifically outlines the potential effect of glyphosate exposure on the composition and functionality of the gut microbiome. Evidence has been building behind the hypothesis that the composition of each individual gut microbiota significantly impacts health. For this reason, the potential of glyphosate to inhibit the growth of beneficial microbes in the gut or alter their functionality is an important topic that warrants further consideration.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid2263935.en
dc.identifier.citationWalsh, L., Hill, C. and Ross, R.P. (2023) ‘Impact of glyphosate (Roundup TM ) on the composition and functionality of the gut microbiome’, Gut Microbes, 15(2), 2263935 (16pp). doi: 10.1080/19490976.2023.2263935en
dc.identifier.doi10.1080/19490976.2023.2263935en
dc.identifier.eissn1949-0984en
dc.identifier.endpage16en
dc.identifier.issn1949-0976en
dc.identifier.issued2en
dc.identifier.journaltitleGut Microbesen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/15671
dc.identifier.volume15en
dc.language.isoenen
dc.publisherTaylor and Francis Ltd.en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/HE::ERC::HORIZON-ERC/101054719/EU/Bacteriocins from interbacterial warfare as antibiotic alternative/BACtheWINNERen
dc.rights© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consenten
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectGlyphosateen
dc.subjectGut microbiomeen
dc.subjectAntimicrobialen
dc.subjectHuman healthen
dc.subjectRoundupTMen
dc.titleImpact of glyphosate (RoundupTM) on the composition and functionality of the gut microbiomeen
dc.typeArticle (peer-reviewed)en
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