The microbiota of the mother at birth and its influence on the emerging infant oral microbiota from birth to 1 year of age: a cohort study

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dc.contributor.authorHurley, Eimear
dc.contributor.authorMullins, David
dc.contributor.authorBarrett, Maurice P. J.
dc.contributor.authorO'Shea, Carol Anne
dc.contributor.authorKinirons, Martin
dc.contributor.authorRyan, C. Anthony
dc.contributor.authorStanton, Catherine
dc.contributor.authorWhelton, Helen
dc.contributor.authorHarris, Hugh M. B.
dc.contributor.authorO'Toole, Paul W.
dc.contributor.funderHealth Research Boarden
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderDepartment of Agriculture, Food and the Marineen
dc.date.accessioned2019-11-20T05:01:05Z
dc.date.available2019-11-20T05:01:05Z
dc.date.issued2019-04-26
dc.description.abstractBackground: The acquisition of microbial communities and the influence of delivery mode on the oral microbiota of the newborn infant remains poorly characterised. Methods: A cohort of pregnant women were enrolled in the study (n = 84). All infants were born full term, by Spontaneous vaginal delivery (SVD) or by Caesarean section (CS). At delivery a saliva sample along with a vaginal/skin sample from the mother. Saliva samples were the taken from the infant within one week of birth, and at week 4, week 8, 6 months and 1 year of age. We used high-throughput sequencing of V4-V5 region 16S rRNA amplicons to compare the microbiota of all samples. Results: The vaginal microbiota had a lower alpha diversity than the skin microbiota of the mother, while the infant oral microbiota diversity remained relatively stable from birth to 8 weeks of age. The oral microbiota of the neonate differed by birth modality up to 1 week of age (p < 0.05), but birth modality did not have any influence on the infant oral microbiota beyond this age. Conclusions: We conclude thatbirth mode does not have an effect on the infant oral microbiota beyond 4 weeks of age, and the oral microbiota of infants continues to develop until 1 year of age.en
dc.description.sponsorshipHRA_POR/2012/123; ORALMET study; Infantmet projecten
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid1599652en
dc.identifier.citationHurley, E., Mullins, D., Barrett, M.P., O’Shea, C.A., Kinirons, M., Ryan, C.A., Stanton, C., Whelton, H., Harris, H.M. and O’Toole, P.W., 2019. The microbiota of the mother at birth and its influence on the emerging infant oral microbiota from birth to 1 year of age: a cohort study. Journal of Oral Microbiology, 11(1), (1599652). DOI:10.1080/20002297.2019.1599652en
dc.identifier.doi10.1080/20002297.2019.1599652en
dc.identifier.eissn2000-2297
dc.identifier.endpage19en
dc.identifier.issued1en
dc.identifier.journaltitleJournal of Oral Microbiologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9104
dc.identifier.volume11en
dc.language.isoenen
dc.publisherTaylor and Francis Ltd.en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.urihttps://www.tandfonline.com/doi/full/10.1080/20002297.2019.1599652
dc.rights© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Groupen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectMicrobiotaen
dc.subjectVaginaen
dc.subjectSkinen
dc.subjectMotheren
dc.subjectTransmissionen
dc.subjectOral cavityen
dc.subjectSalivaen
dc.subjectNewbornen
dc.subjectInfanten
dc.titleThe microbiota of the mother at birth and its influence on the emerging infant oral microbiota from birth to 1 year of age: a cohort studyen
dc.typeArticle (peer-reviewed)en
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