EAACI Biologicals Guidelines - Recommendations for severe asthma

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dc.contributor.authorAgache, Ioana
dc.contributor.authorAkdis, Cezmi A.
dc.contributor.authorAkdis, Mubeccel
dc.contributor.authorCanonica, Giorgio Walter
dc.contributor.authorCasale, Thomas
dc.contributor.authorChivato, Tomas
dc.contributor.authorCorren, Jonathan
dc.contributor.authorChu, Derek K.
dc.contributor.authorDel Giacco, Stefano
dc.contributor.authorEiwegger, Thomas
dc.contributor.authorFlood, Breda
dc.contributor.authorFirinu, Davide
dc.contributor.authorGern, James E.
dc.contributor.authorHamelmann, Eckard
dc.contributor.authorHanania, Nicola
dc.contributor.authorHernández-Martí­n, Irene
dc.contributor.authorKnibb, Rebeca
dc.contributor.authorMäkelä, Mika
dc.contributor.authorNair, Parameswaran
dc.contributor.authorO'Mahony, Liam
dc.contributor.authorPapadopoulos, Nikolaos G.
dc.contributor.authorPapi, Alberto
dc.contributor.authorPark, Hae-Sim
dc.contributor.authorPérez de Llano, Luis
dc.contributor.authorPfaar, Oliver
dc.contributor.authorQuirce, Santiago
dc.contributor.authorSastre, Joaquin
dc.contributor.authorShamji, Mohamed
dc.contributor.authorSchwarze, Jurgen
dc.contributor.authorPalomares, Oscar
dc.contributor.authorJutel, Marek
dc.date.accessioned2021-07-05T11:20:08Z
dc.date.available2021-07-05T11:20:08Z
dc.date.issued2020-06-02
dc.date.updated2021-07-05T11:01:08Z
dc.description.abstractSevere asthma imposes a significant burden on patients, families and healthcare systems. Management is difficult, due to disease heterogeneity, co-morbidities, complexity in care pathways and differences between national or regional healthcare systems. Better understanding of the mechanisms has enabled a stratified approach to the management of severe asthma, supporting the use of targeted treatments with biologicals. However, there are still many issues that require further clarification. These include selection of a certain biological (as they all target overlapping disease phenotypes), the definition of response, strategies to enhance the responder rate, the duration of treatment and its regimen (in the clinic or home-based) and its cost-effectiveness. The EAACI Guidelines on the use of biologicals in severe asthma follow the GRADE approach in formulating recommendations for each biological and each outcome. In addition, a management algorithm for the use of biologicals in the clinic is proposed, together with future approaches and research priorities.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAgache, I., Akdis, C. A., Akdis, M., Canonica, G. W., Casale, T., Chivato, T., Corren, J., Chu, D. K., Del Giacco, S., Eiwegger, T., Flood, B., Firinu, D., Gern, J. E., Hamelmann, E., Hanania, N., Hernández-Martí­n, I., Knibb, R., Mäkelä, M., Nair, P., O'Mahony, L., Papadopoulos, N. G., Papi, A., Park, H.-S., Pérez de Llano, L., Pfaar, O., Quirce, S., Sastre, J., Shamji, M., Schwarze, J., Palomares, O. and Jutel, M. (2020) 'EAACI Biologicals Guidelines - Recommendations for severe asthma', Allergy, 76(1), pp. 14-44. doi: 10.1111/all.14425en
dc.identifier.doi10.1111/all.14425en
dc.identifier.eissn1398-9995
dc.identifier.endpage44en
dc.identifier.issn0105-4538
dc.identifier.issued1en
dc.identifier.journaltitleAllergyen
dc.identifier.startpage14en
dc.identifier.urihttps://hdl.handle.net/10468/11535
dc.identifier.volume76en
dc.language.isoenen
dc.publisherJohn Wiley & Sons, Inc.en
dc.rights© 2020, EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd. This is the peer reviewed version of the following article: Agache, I., Akdis, C. A., Akdis, M., Canonica, G. W., Casale, T., Chivato, T., Corren, J., Chu, D. K., Del Giacco, S., Eiwegger, T., Flood, B., Firinu, D., Gern, J. E., Hamelmann, E., Hanania, N., Hernández-Martí­n, I., Knibb, R., Mäkelä, M., Nair, P., O'Mahony, L., Papadopoulos, N. G., Papi, A., Park, H.-S., Pérez de Llano, L., Pfaar, O., Quirce, S., Sastre, J., Shamji, M., Schwarze, J., Palomares, O. and Jutel, M. (2020) 'EAACI Biologicals Guidelines - Recommendations for severe asthma', Allergy, 76(1), pp. 14-44, doi: 10.1111/all.14425, which has been published in final form at: https://doi.org/10.1111/all.14425 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en
dc.subjectBiologicalsen
dc.subjectCost-effectivenessen
dc.subjectGRADEen
dc.subjectGuidelinesen
dc.subjectSevere asthmaen
dc.titleEAACI Biologicals Guidelines - Recommendations for severe asthmaen
dc.typeArticle (peer-reviewed)en
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