Melatonin as a reactive treatment for post-operative delirium in patients in the cardiac ICU: a retrospective cohort study
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Date
2025
Authors
Clarke, Andres
Hinchion, John
Journal Title
Journal ISSN
Volume Title
Publisher
UCC Medical Research and Technology Society
Published Version
Abstract
Introduction: ICU delirium is a significant problem in post-operative cardiothoracic patients, contributing to prolonged ICU and hospital stays and increased mortality. Current pharmacological treatments, such as benzodiazepines and antipsychotics, have notable adverse effects, leading to interest in safer alternatives. A systematic review has shown melatonin’s effectiveness as a prophylactic agent for delirium in surgical and ICU patients. This study aims to assess the use of melatonin as a reactive therapeutic agent in post-operative delirium in cardiac ICU patients. Methods: This retrospective cohort study analysed data from 127 patients diagnosed with delirium, confirmed through a positive CAM-ICU score. Patients were divided into two groups: one that received melatonin (n=57) as part of their delirium management and another that did not (n=70). The primary outcome was delirium regression, measured by a negative CAM-ICU score during the ICU stay. Secondary outcomes included ICU length of stay, hospital l
Description
Keywords
Melatonin , Post-operative delirium , Cardiac ICU , Retrospective cohort study
Citation
Clarke, A. and Hinchion, J. (2025) 'Melatonin as a reactive treatment for post-operative delirium in patients in the cardiac ICU: a retrospective cohort study', UCC Student Medical Journal, 5, p. 110. https://doi.org/10.33178/SMJ.2025.1.36