Melatonin as a reactive treatment for post-operative delirium in patients in the cardiac ICU: a retrospective cohort study

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dc.contributor.authorClarke, Andresen
dc.contributor.authorHinchion, Johnen
dc.contributor.editorMehta, Shobhaen
dc.contributor.editorCronin, Pádraigen
dc.date.accessioned2025-10-28T13:55:05Z
dc.date.available2025-10-28T13:55:05Z
dc.date.issued2025en
dc.description.abstractIntroduction: ICU delirium is a significant problem in post-operative cardiothoracic patients, contributing to prolonged ICU and hospital stays and increased mortality. Current pharmacological treatments, such as benzodiazepines and antipsychotics, have notable adverse effects, leading to interest in safer alternatives. A systematic review has shown melatonin’s effectiveness as a prophylactic agent for delirium in surgical and ICU patients. This study aims to assess the use of melatonin as a reactive therapeutic agent in post-operative delirium in cardiac ICU patients. Methods: This retrospective cohort study analysed data from 127 patients diagnosed with delirium, confirmed through a positive CAM-ICU score. Patients were divided into two groups: one that received melatonin (n=57) as part of their delirium management and another that did not (n=70). The primary outcome was delirium regression, measured by a negative CAM-ICU score during the ICU stay. Secondary outcomes included ICU length of stay, hospital len
dc.description.statusNot peer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationClarke, A. and Hinchion, J. (2025) 'Melatonin as a reactive treatment for post-operative delirium in patients in the cardiac ICU: a retrospective cohort study', UCC Student Medical Journal, 5, p. 110. https://doi.org/10.33178/SMJ.2025.1.36en
dc.identifier.doi10.33178/SMJ.2025.1.36en
dc.identifier.endpage110en
dc.identifier.issn2737-7237
dc.identifier.journalabbrevUCC SMJ
dc.identifier.journaltitleUCC Student Medical Journalen
dc.identifier.startpage110en
dc.identifier.urihttps://hdl.handle.net/10468/18113
dc.identifier.volume5
dc.language.isoenen
dc.publisherUCC Medical Research and Technology Societyen
dc.rights© 2025, the Author(s). This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.sourceBatch uploaden
dc.subjectMelatoninen
dc.subjectPost-operative deliriumen
dc.subjectCardiac ICUen
dc.subjectRetrospective cohort studyen
dc.titleMelatonin as a reactive treatment for post-operative delirium in patients in the cardiac ICU: a retrospective cohort studyen
dc.typeConference itemen
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