Risk factors and birth outcomes of anaemia in early pregnancy in a nulliparous cohort

dc.contributor.authorMasukume, Gwinyai
dc.contributor.authorKhashan, Ali S.
dc.contributor.authorKenny, Louise C.
dc.contributor.authorBaker, Philip N.
dc.contributor.authorNelson, Gill
dc.contributor.funderRMIT University, Australia
dc.contributor.funderFoundation for Research, Science and Technology, New Zealand
dc.contributor.funderHealth Research Council, New Zealand
dc.contributor.funderEvelyn Bond Fund, New Zealand
dc.contributor.funderAuckland District Health Board Charitable Trust, New Zealand
dc.contributor.funderGovernment of South Australia
dc.contributor.funderGuy's and St Thomas' Charity
dc.contributor.funderTommy's Baby Charity
dc.contributor.funderBiotechnology and Biological Sciences Research Council
dc.contributor.funderNational Health Service, United Kingdom
dc.contributor.funderUniversity of Manchester, United Kingdom
dc.contributor.funderNational Institute for Health Research, United Kingdom
dc.contributor.funderCerebra, United Kingdom
dc.contributor.funderHealth Research Board
dc.description.abstractBackground: Anaemia in pregnancy is a major public health and economic problem worldwide, that contributes to both maternal and fetal morbidity and mortality. Objective: The aim of the study was to calculate the prevalence of anaemia in early pregnancy in a cohort of 'low risk' women participating in a large international multicentre prospective study (n = 5 609), to identify the modifiable risk factors for anaemia in pregnancy in this cohort, and to compare the birth outcomes between pregnancies with and without anaemia in early gestation. Methods: The study is an analysis of data that were collected prospectively during the Screening for Pregnancy Endpoints study. Anaemia was defined according to the World Health Organization's definition of anaemia in pregnancy (haemoglobin <11g/dL). Binary logistic regression with adjustment for potential confounders (country, maternal age, having a marital partner, ethnic origin, years of schooling, and having paid work) was the main method of analysis. Results: The hallmark findings were the low prevalence of anaemia (2.2%), that having no marital partner was an independent risk factor for having anaemia (OR 1.34, 95% CI 1.01-1.78), and that there was no statistically significant effect of anaemia on adverse pregnancy outcomes (small for gestational age, pre-tem birth, mode of delivery, low birth weight, APGAR score < 7 at one and five minutes). Adverse pregnancy outcomes were however more common in those with anaemia than in those without. Conclusion: In this low risk healthy pregnant population we found a low anaemia rate. The absence of a marital partner was a non-modifiable factor, albeit one which may reflect a variety of confounding factors, that should be considered for addition to anaemia's conceptual framework of determinants. Although not statistically significant, clinically, a trend towards a higher risk of adverse pregnancy outcomes was observed in women that were anaemic in early pregnancy.en
dc.description.sponsorshipRMIT University, Australia (New Enterprise Research Fund); Health Research Council, New Zealand (04/198); Government of South Australia (Premier's Science and Research Fund); Biotechnology and Biological Sciences Research Council, United Kingdom (GT084); National Health Service, United Kingdom (NEAT FSD025); University of Manchester (Proof of Concept Funding); Health Research Board, Ireland (CSA/2007/2)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.identifier.citationMasukume G, Khashan AS, Kenny LC, Baker PN, Nelson G, SCOPE Consortium (2015) Risk Factors and Birth Outcomes of Anaemia in Early Pregnancy in a Nulliparous Cohort. PLoS ONE 10(4): e0122729. doi:10.1371/journal.pone.0122729
dc.identifier.journaltitlePLOS ONEen
dc.publisherPublic Library of Scienceen
dc.rights© 2015 Masukume et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are crediteden
dc.subjectIron deficiencyen
dc.subjectMaternal anemiaen
dc.titleRisk factors and birth outcomes of anaemia in early pregnancy in a nulliparous cohorten
dc.typeArticle (peer-reviewed)en
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