Goal attainment, medication adherence and guideline adherence in the treatment of hypertension and dyslipidemia in Irish populations: A systematic review and meta-analysis

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dc.contributor.authorElhiny, Rehaben
dc.contributor.authorO'Keeffe, Linda M.en
dc.contributor.authorBodunde, Elizabeth O.en
dc.contributor.authorByrne, Stephenen
dc.contributor.authorDonovan, Mariaen
dc.contributor.authorBermingham, Margareten
dc.contributor.funderNovartisen
dc.contributor.funderMinistry of Higher Education and Scientific Researchen
dc.date.accessioned2025-10-06T13:11:28Z
dc.date.available2025-10-06T13:11:28Z
dc.date.issued2025-01-13en
dc.description.abstractBackground: The appropriate treatment high blood pressure (BP) and low-density lipoprotein cholesterol. (LDL-C), according to clinical guidelines, reduces a patient's risk of a cardiovascular event. Aim: This systematic review aims to evaluate the attainment of BP and LDL-C goals among the Irish population in both primary and secondary prevention of cardiovascular diseases, the level of adherence to prescribing guidelines by doctors and the level of medication adherence among patients. Methods: Five databases were searched in March 2024. Quantitative articles reporting levels of goals attainment, medication adherence or guideline adherence for LDL-C and BP among Irish adults aged ≥18 years were included. The proportion of patients attaining their LDL-Cor BP goals were statistically combined using the random effect model. Results: Following screening, 23 eligible articles were identified. The achievement of LDL-C <1.8 mmol/L was 41 % (95 % CI 31,52), compared to 69 % of people (95 % CI 62,76) reported to have achieved the less stringent goal of LDL-C < 3 mmol/L. The achievement of BP < 140/90 mmHg was 56 % (95 % CI 46,65). Medication adherence levels ranged between 27 % and 92 %. Guideline adherence findings demonstrated that not all patients who should be on lipid-lowering therapy are and that choice of antihypertensive is not always in line with the guidelines. Conclusion: Approximately one-third of deaths in Ireland annually are caused by cardiovascular disease, despite being preventable. There is room for improvement in goal attainments in people at risk of CVDs and optimization of medication adherence and guideline adherence may be beneficial in this population.en
dc.description.sponsorshipMinistry of Higher Education and Scientific Research, Cairo, Egypt (Graduate Studies Scholarship)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid200364en
dc.identifier.citationElhiny, R., O'Keeffe, L. M., Bodunde, E. O., Byrne, S., Donovan, M. and Bermingham, M. (2025) 'Goal attainment, medication adherence and guideline adherence in the treatment of hypertension and dyslipidemia in Irish populations: A systematic review and meta-analysis', International Journal of Cardiology Cardiovascular Risk and Prevention, 24, 200364 (15pp). https://doi.org/10.1016/j.ijcrp.2025.200364en
dc.identifier.doi10.1016/j.ijcrp.2025.200364en
dc.identifier.endpage15en
dc.identifier.issn2772-4875en
dc.identifier.journaltitleInternational Journal of Cardiology Cardiovascular Risk and Preventionen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/17961
dc.identifier.volume24en
dc.language.isoenen
dc.publisherElsevier Ltd.en
dc.relation.ispartofInternational Journal of Cardiology Cardiovascular Risk and Preventionen
dc.rights© 2025, the Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectBlood pressure goal achievementsen
dc.subjectLDL-C goal achievementsen
dc.subjectMedication adherenceen
dc.subjectGuideline adherenceen
dc.subjectCardiovascular risk factors controlen
dc.titleGoal attainment, medication adherence and guideline adherence in the treatment of hypertension and dyslipidemia in Irish populations: A systematic review and meta-analysisen
dc.typeArticle (peer-reviewed)en
dc.typejournal-articleen
oaire.citation.volume24en
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