Maternal marijuana use has independent effects on risk for spontaneous preterm birth but not other common late pregnancy complications

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dc.contributor.authorLeemaqz, Shalem Y.
dc.contributor.authorDekker, Gustaaf A.
dc.contributor.authorMcCowan, Lesley M. E.
dc.contributor.authorKenny, Louise C.
dc.contributor.authorMyers, Jenny E.
dc.contributor.authorSimpson, Nigel A. B.
dc.contributor.authorPoston, Lucilla
dc.contributor.authorRoberts, Claire T.
dc.contributor.funderNational Health and Medical Research Councilen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderFoundation for Research, Science and Technologyen
dc.contributor.funderNational Health and Medical Research Councilen
dc.contributor.funderEvelyn Bond Funden
dc.contributor.funderAuckland District Health Board Charitable Trusten
dc.contributor.funderHealth Research Boarden
dc.contributor.funderOxford University Hospitals NHS Foundation Trusten
dc.contributor.funderBiotechnology and Biological Sciences Research Councilen
dc.contributor.funderUniversity of Manchesteren
dc.contributor.funderKing’s College Londonen
dc.contributor.funderUniversity of Leedsen
dc.contributor.funderNew Enterprise Research Funden
dc.date.accessioned2019-11-27T11:45:33Z
dc.date.available2019-11-27T11:45:33Z
dc.date.issued2016-04-30
dc.description.abstractWidespread legalisation of marijuana raises safety concerns for its use in pregnancy. This study investigated the association of marijuana use prior to and during pregnancy with pregnancy outcomes in a prospective cohort of 5588 nulliparous women from the international SCOPE study. Women were assessed at 15 ± 1 and 20 ± 1 weeks’ gestation. Cases [278 Preeclampsia, 470 gestational hypertension, 633 small-for-gestational-age, 236 spontaneous preterm births (SPTB), 143 gestational diabetes] were compared separately with 4114 non-cases. Although the numbers are small, continued maternal marijuana use at 20 weeks’ gestation was associated with SPTB independent of cigarette smoking status [adj OR 2.28 (95% CI:1.45–3.59)] and socioeconomic index (SEI) [adj OR 2.17 (95% CI:1.41–3.34)]. When adjusted for maternal age, cigarette smoking, alcohol and SEI, continued maternal marijuana use at 20 weeks’ gestation had a greater effect size [adj OR 5.44 (95% CI 2.44–12.11)]. Our data indicate that increasing use of marijuana among young women of reproductive age is a major public health concern.en
dc.description.sponsorshipNational Health and Medical Research Council (GNT1020749, GNT519225); Health Research Council [04/198]; Health Research Board of Ireland [CSA/2007/2]; National Health Service NEAT Grant [Neat Grant FSD025]; Biotechnology and Biological Sciences Research council [GT084]en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationLeemaqz, S. Y., Dekker, G. A., McCowan, L. M., Kenny, L. C., Myers, J. E., Simpson, N. A. B., Poston, L. and Roberts, C. T. (2016) 'Maternal marijuana use has independent effects on risk for spontaneous preterm birth but not other common late pregnancy complications', Reproductive Toxicology, 62, pp. 77-86. doi: 10.1016/j.reprotox.2016.04.021en
dc.identifier.doi10.1016/j.reprotox.2016.04.021en
dc.identifier.eissn1873-1708
dc.identifier.endpage86en
dc.identifier.issn0890-6238
dc.identifier.journaltitleReproductive Toxicologyen
dc.identifier.startpage77en
dc.identifier.urihttps://hdl.handle.net/10468/9266
dc.identifier.volume62en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/en
dc.rights©2016 The Author(s). Published by Elsevier Inc. Under a Creative Commons licenseen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectMarijuanaen
dc.subjectSmokingen
dc.subjectBMIen
dc.subjectPregnancy outcomeen
dc.subjectSpontaneous preterm birthen
dc.titleMaternal marijuana use has independent effects on risk for spontaneous preterm birth but not other common late pregnancy complicationsen
dc.typeArticle (peer-reviewed)en
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