Toxicity assessment of ZnO-decorated Au nanoparticles in the Mediterranean clam Ruditapes decussatus
| dc.check.date | 2019-04-15 | |
| dc.check.info | Access to this article is restricted until 24 months after publication at the request of the publisher. | en |
| dc.contributor.author | Sellami, Badreddine | |
| dc.contributor.author | Mezni, Amine | |
| dc.contributor.author | Khazri, Abdelhafidh | |
| dc.contributor.author | Bouzidi, Imen | |
| dc.contributor.author | Saidani, Wiem | |
| dc.contributor.author | Sheehan, David | |
| dc.contributor.author | Beyrem, Hamouda | |
| dc.contributor.funder | University College Cork | en |
| dc.contributor.funder | National Institute of Marine Sciences and Technologies, Tunisia | |
| dc.contributor.funder | Ministry of Higher Education of Carthage, Tunisia | |
| dc.contributor.funder | University of Carthage | |
| dc.date.accessioned | 2017-06-19T13:42:35Z | |
| dc.date.available | 2017-06-19T13:42:35Z | |
| dc.date.issued | 2017-04-15 | |
| dc.date.updated | 2017-06-19T13:29:25Z | |
| dc.description.abstract | The synthesis of hybrid nanomaterials has greatly increased in recent years due to their special physical and chemical properties. However, information regarding the environmental toxicity associated with these chemicals is limited, in particular in the aquatic environment. In the present study, an experiment was performed in which the marine bivalve (Ruditapes decussatus) was exposed for 14 days to 2 concentrations of zinc oxide-decorated Au nanoparticles (Au-ZnONPs: Au-ZnONP50 = 50 μg/L; Au-ZnONP100 = 100 μg/L). The stability and resistance of Au-ZnONPs in the natural seawater were assessed by combining transmission electron microscopy and dynamic light scattering. Inductively coupled plasma-atomic emission spectroscopy revealed uptake of these nanoparticles within clams and their ability to induce metallic deregulation. The results obtained indicate that Au-ZnONPs induce biochemical and histological alterations within either the digestive gland or gill tissues at high concentration. This was deduced from the significant increase in H2O2 level, superoxide dismutase and catalase activities and malondialdehyde content. Furthermore, the toxicity of Au-ZnO nanoparticles was linked with the increase of intracellular iron and calcium levels in both tissues. Histological alterations in gill and digestive gland were more pronounced with Au-ZnONP100 and this is likely related to oxidative mechanisms. Gill and digestive gland are differentially sensitive to Au-ZnONPs if the exposure concentration is higher than 50 μg/L. In conclusion, the parameters considered here could constitute reliable biomarkers for evaluation of hybrid nanoparticles toxicity in environmental model organisms. In addition, based on the results obtained, gill and digestive gland of R. decussatus could be proposed as models to detect harmful effects of hybrid nanoparticles. | en |
| dc.description.sponsorship | National Institute of Marine Sciences and Technologies, Tunisia; The Ministry of Higher Education of Carthage, Tunisia; Laboratory of Environment Biomonitoring; Department of Chemistry, Faculty of Sciences of Bizerte, University of Carthage, Tunisia; Environmental Research Institute and School of Biochemistry and Cell Biology, University College Cork. | en |
| dc.description.status | Peer reviewed | en |
| dc.description.version | Accepted Version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Sellami, B., Mezni, A., Khazri, A., Bouzidi, I., Saidani, W., Sheehan, D. and Beyrem, H. (2017) 'Toxicity assessment of ZnO-decorated Au nanoparticles in the Mediterranean clam Ruditapes decussatus', Aquatic Toxicology, 188, pp. 10-19. doi:10.1016/j.aquatox.2017.04.005 | en |
| dc.identifier.doi | 10.1016/j.aquatox.2017.04.005 | |
| dc.identifier.endpage | 19 | en |
| dc.identifier.issn | 0166-445X | |
| dc.identifier.journaltitle | Aquatic Toxicology | en |
| dc.identifier.startpage | 10 | en |
| dc.identifier.uri | https://hdl.handle.net/10468/4091 | |
| dc.identifier.volume | 188 | en |
| dc.language.iso | en | en |
| dc.publisher | Elsevier | en |
| dc.rights | © 2017 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license | en |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
| dc.subject | ZnO-decorated Au nanoparticles | en |
| dc.subject | Ruditapes decussatus | en |
| dc.subject | Biomarkers | en |
| dc.subject | Oxidative stress | en |
| dc.title | Toxicity assessment of ZnO-decorated Au nanoparticles in the Mediterranean clam Ruditapes decussatus | en |
| dc.type | Article (peer-reviewed) | en |
