Synergistic nisin-polymyxin combinations for the control of Pseudomonas biofilm formation

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dc.contributor.authorField, Des
dc.contributor.authorSeisling, Nynke
dc.contributor.authorCotter, Paul D.
dc.contributor.authorRoss, R. Paul
dc.contributor.authorHill, Colin
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderEuropean Social Funden
dc.date.accessioned2016-10-28T15:38:52Z
dc.date.available2016-10-28T15:38:52Z
dc.date.issued2016-10-26
dc.description.abstractThe emergence and dissemination of multi-drug resistant pathogens is a global concern. Moreover, even greater levels of resistance are conferred on bacteria when in the form of biofilms (i.e., complex, sessile communities of bacteria embedded in an organic polymer matrix). For decades, antimicrobial peptides have been hailed as a potential solution to the paucity of novel antibiotics, either as natural inhibitors that can be used alone or in formulations with synergistically acting antibiotics. Here, we evaluate the potential of the antimicrobial peptide nisin to increase the efficacy of the antibiotics polymyxin and colistin, with a particular focus on their application to prevent biofilm formation of Pseudomonas aeruginosa. The results reveal that the concentrations of polymyxins that are required to effectively inhibit biofilm formation can be dramatically reduced when combined with nisin, thereby enhancing efficacy, and ultimately, restoring sensitivity. Such combination therapy may yield added benefits by virtue of reducing polymyxin toxicity through the administration of significantly lower levels of polymyxin antibiotics.en
dc.description.sponsorshipScience Foundation Ireland (SFI Technology and Innovation Development Award (TIDA 14/TIDA/2286), SFI Investigator awards (10/IN.1/B3027), SFI-PI funding (11/PI/1137), (Grant Number SFI/12/RC/2273)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationField, D., Seisling, N., Cotter, P. D., Ross, R. P. and Hill, C. (2016) ‘Synergistic nisin-polymyxin combinations for the control of Pseudomonas biofilm formation. Frontiers in Microbiology, 7, 1713 (7pp). doi: 10.3389/fmicb.2016.01713en
dc.identifier.doi10.3389/fmicb.2016.01713
dc.identifier.endpage1713-7en
dc.identifier.issn1664-302X
dc.identifier.journaltitleFrontiers in Microbiologyen
dc.identifier.startpage1713-1en
dc.identifier.urihttps://hdl.handle.net/10468/3228
dc.identifier.volume7en
dc.language.isoenen
dc.publisherFrontiers Mediaen
dc.rights© 2016 Field, Seisling, Cotter, Ross and Hill. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectBiofilmen
dc.subjectColistinen
dc.subjectPolymyxinen
dc.subjectNisinen
dc.subjectLantibioticen
dc.subjectP. aeruginosaen
dc.subjectBacteriocinen
dc.subjectAntibioticsen
dc.titleSynergistic nisin-polymyxin combinations for the control of Pseudomonas biofilm formationen
dc.typeArticle (peer-reviewed)en
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