Relationship between body mass index, risk of venous thromboembolism and pulmonary embolism: A systematic review and dose-response meta-analysis of cohort studies among four million participants

Simple item page
dc.contributor.authorRahmani, Jamalen
dc.contributor.authorHaghighian Roudsari, Arezooen
dc.contributor.authorBawadi, Hibaen
dc.contributor.authorThompson, Jacquelineen
dc.contributor.authorKhalooei Fard, Raziehen
dc.contributor.authorClark, Cainen
dc.contributor.authorRyan, Paul M.en
dc.contributor.authorAjami, Marjanen
dc.contributor.authorRahimi Sakak, Fatemehen
dc.contributor.authorSalehisahlabadi, Ammaren
dc.contributor.authorAbdulazeem, Hebatullah M.en
dc.contributor.authorJamali, Mohammad Rezaen
dc.contributor.authorRazaz, Jalaledin Mirzayen
dc.date.accessioned2023-10-17T14:11:07Z
dc.date.available2023-10-17T14:11:07Z
dc.date.issued2020-05-13en
dc.description.abstractBackground: The relationship between body mass index (BMI) and risk of venous thromboembolism (VTE) and pulmonary embolism (PE) is a controversial issue. This dose-response meta-analysis was performed to investigate the association between BMI and risk of VTE and PE incidence based on cohort studies. Method:A comprehensive systematic search was conducted up to August 2019 in MEDLINE/PubMed, SCOPUS, and Cochrane. DerSimonian and Laird random-effects models were run to estimate combined hazard ratios (HRs) with 95% confidence intervals (CIs). Dose-response analysis was also carried out based on BMI values. Results: Eleven articles with 16 arms and 3,910,747 participants were eligible for inclusion in this systematic review and meta-analysis. Pooled results showed a positive association between BMI and risk of VTE in the obese participants compared to participants classified in the normal BMI category (HR: 1.62, 95% CI: 1.29–2.04, I2 = 95%). Furthermore, results showed a significant association between lower BMI (underweight versus normal BMI category) and reduced risk of PE (HR: 0.80, 95% CI: 0.70–0.92, I2 = 9%) and higher risk of PE in obese versus normal BMI participants (HR: 2.24, 95% CI: 1.93–2.60, I2 = 0%). There was a significant linear relationship between BMI and risk of VTE (p < 0.001) and PE (p < 0.001). Conclusions: This systematic review and dose-response meta-analysis with 3,910,747 participants highlights obesity as a significant risk factor related to the incidence of VTE and PE.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationRahmani, J., Haghighian Roudsari, A., Bawadi, H., Thompson, J., Khalooei Fard, R., Clark, C., Ryan, P. M., Ajami, M., Sakak, F. R., Salehisahlabadi, A., Abdulazeem, H. M., Jamali, M. R. and Razaz, J. M. (2020) 'Relationship between body mass index, risk of venous thromboembolism and pulmonary embolism: A systematic review and dose-response meta-analysis of cohort studies among four million participants', Thrombosis Research, 192, pp.64-72. doi: 10.1016/j.thromres.2020.05.014en
dc.identifier.doi10.1016/j.thromres.2020.05.014en
dc.identifier.endpage72en
dc.identifier.issn0049-3848en
dc.identifier.journaltitleThrombosis Researchen
dc.identifier.startpage64en
dc.identifier.urihttps://hdl.handle.net/10468/15128
dc.identifier.volume192en
dc.language.isoenen
dc.publisherElsevier Inc.en
dc.rights© 2020, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectBody mass indexen
dc.subjectVenous thromboembolismen
dc.subjectPulmonary embolismen
dc.titleRelationship between body mass index, risk of venous thromboembolism and pulmonary embolism: A systematic review and dose-response meta-analysis of cohort studies among four million participantsen
dc.typeArticle (peer-reviewed)en
oaire.citation.volume192en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Binder4.pdf
Size:
268.52 KB
Format:
Adobe Portable Document Format
Description:
Accepted Version
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medicine - Journal Articles