Linking human milk oligosaccharide metabolism and early life gut microbiota: bifidobacteria and beyond

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dc.check.date11/07/2024en
dc.check.infoAccess to this article is restricted until 6 months after publication by request of the publisheren
dc.contributor.authorLordan, Cathyen
dc.contributor.authorRoche, Aoife K.en
dc.contributor.authorDelsing, Dianneen
dc.contributor.authorNauta, Arjenen
dc.contributor.authorGroeneveld, Andreen
dc.contributor.authorMacSharry, Johnen
dc.contributor.authorCotter, Paul D.en
dc.contributor.authorvan Sinderen, Douween
dc.contributor.editorRey, Federicoen
dc.contributor.funderFrieslandCampinaen
dc.date.accessioned2024-04-18T11:47:21Z
dc.date.available2024-04-18T11:47:21Z
dc.date.issued2024-01-11en
dc.description.abstractHuman milk oligosaccharides (HMOs) are complex, multi-functional glycans present in human breast milk. They represent an intricate mix of heterogeneous structures which reach the infant intestine in an intact form as they resist gastrointestinal digestion. Therefore, they confer a multitude of benefits, directly and/or indirectly, to the developing neonate. Certain bifidobacterial species, being among the earliest gut colonizers of breast-fed infants, have an adapted functional capacity to metabolize various HMO structures. This ability is typically observed in infant-associated bifidobacteria, as opposed to bifidobacteria associated with a mature microbiota. In recent years, information has been gleaned regarding how these infant-associated bifidobacteria as well as certain other taxa are able to assimilate HMOs, including the mechanistic strategies enabling their acquisition and consumption. Additionally, complex metabolic interactions occur between microbes facilitated by HMOs, including the utilization of breakdown products released from HMO degradation. Interest in HMO-mediated changes in microbial composition and function has been the focal point of numerous studies, in recent times fueled by the availability of individual biosynthetic HMOs, some of which are now commonly included in infant formula. In this review, we outline the main HMO assimilatory and catabolic strategies employed by infant-associated bifidobacteria, discuss other taxa that exhibit breast milk glycan degradation capacity, and cover HMO-supported cross-feeding interactions and related metabolites that have been described thus far.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide00094-23en
dc.identifier.citationLordan, C., Roche, A. K., Delsing, D., Nauta, A., Groeneveld, A., MacSharry, J., Cotter, P. D. and van Sinderen. D. (2024) 'Linking human milk oligosaccharide metabolism and early life gut microbiota: bifidobacteria and beyond', Microbiology and Molecular Biology Reviews, 88(1), e00094-23 (38pp). https://doi.org/10.1128/mmbr.00094-23en
dc.identifier.doihttps://doi.org/10.1128/mmbr.00094-23en
dc.identifier.eissn1098-5557en
dc.identifier.endpage38en
dc.identifier.issn1092-2172en
dc.identifier.issued1en
dc.identifier.journaltitleMicrobiology and Molecular Biology Reviewsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/15812
dc.identifier.volume88en
dc.language.isoenen
dc.publisherAmerican Society for Microbiologyen
dc.rights© 2024, American Society for Microbiology. All Rights Reserved.en
dc.subjectInfant microbiomeen
dc.subjectHuman milk oligosaccharidesen
dc.subjectGut microbiotaen
dc.subjectInfanten
dc.subjectBifidobacteriaen
dc.titleLinking human milk oligosaccharide metabolism and early life gut microbiota: bifidobacteria and beyonden
dc.typeArticle (peer-reviewed)en
oaire.citation.issue1en
oaire.citation.volume88en
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