Characterising a stress-sensitive default mode network (DMN) deficit in major psychiatric disorders

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dc.contributor.authorKing, S.
dc.contributor.authorZhang, Z.
dc.contributor.authorRobinson, L.
dc.contributor.authorWhelan, R.
dc.contributor.authorNees, F.
dc.contributor.authorBobou, M.
dc.contributor.authorBanaschewski, T.
dc.contributor.authorBarker, G.J.
dc.contributor.authorBokde, A.L.W.
dc.contributor.authorFlor, H.
dc.contributor.authorGrigis, A.
dc.contributor.authorGaravan, H.
dc.contributor.authorGowland, P.
dc.contributor.authorHeinz, A.
dc.contributor.authorBrühl, R.
dc.contributor.authorMartinot, J.-L.
dc.contributor.authorMartinot, M.-L.P.
dc.contributor.authorArtiges, E.
dc.contributor.authorPoustka, L.
dc.contributor.authorHohmann, S.
dc.contributor.authorHolz, N.
dc.contributor.authorBaeuchl, C.
dc.contributor.authorSmolka, M.N.
dc.contributor.authorVaidya, N.
dc.contributor.authorWalter, H.
dc.contributor.authorWinterer, J.
dc.contributor.authorBroulidakis, M.J.
dc.contributor.authorvan Noort, B.M.
dc.contributor.authorStringaris, A.
dc.contributor.authorZhang, Y.
dc.contributor.authorSinclair, J.
dc.contributor.authorSchumann, G.
dc.contributor.authorSchmidt, U.
dc.contributor.authorDesrivières, S.
dc.contributor.authorCotter, D.
dc.contributor.authorYoung, A.H.
dc.contributor.authorDonohoe, G.
dc.contributor.authorWolsztynski, E.
dc.contributor.funderAgence nationale de la recherche, ANR
dc.contributor.funderInstitut national de la santé et de la recherche médicale
dc.contributor.funderNational Institute for Health and Care Research, NIHR
dc.contributor.funderFédération pour la Recherche sur le Cerveau, FRC
dc.contributor.funderHorizon 2020 Framework Programme
dc.contributor.funderSouth London and Maudsley NHS Foundation Trust
dc.contributor.funderNIHR Maudsley Biomedical Research Centre
dc.contributor.funderGerman Center for Mental Health
dc.contributor.funderUniversité Paris-Sud
dc.contributor.funderMinistry of Science and Technology of the People's Republic of China, MOST
dc.contributor.funderKing's College London, KCL
dc.contributor.funderEuropean Regional Development Fund, EFRR
dc.contributor.funderDZPG
dc.contributor.funderHorizon 2020
dc.contributor.funderUK Research and Innovation, UKRI
dc.contributor.funderTestosterone and Mental Health, RO1 MH085772-01A1
dc.contributor.funderH2020 Marie Skłodowska-Curie Actions, MSCM, 101034252
dc.contributor.funderANR-12-SAMA-0004, AAPG2019—GeBra
dc.contributor.funderHORIZON EUROPE Framework Programme, 101057429
dc.contributor.funderFondation de l'Avenir pour la Recherche Médicale Appliquée, AP-RM-17-013
dc.contributor.funderBundesministerium für Forschung, Technologie und Raumfahrt, BMBF, 01EE1406B-01EV0711-AERIAL 01EE1406A-01GL1745B-01GS08152
dc.contributor.funderMedical Research Foundation and Medical Research Council, MR/R00465X/1-MR/S020306/1
dc.contributor.funderNational Institutes of Health, USNIH, 1R56AG058854-01-R01DA049238-5U54EB020403-05
dc.contributor.funderDeutsche Forschungsgemeinschaft, DFG, 178833530-402170461-NE 1383/14-1-521379614-IRTG 2773-SFB 940-TRR 265-454245598-386691645-FOR 1617-TRR 393-186318919
dc.contributor.funderEuropean Commission, EU, LSHM-CT- 2007-037286
dc.contributor.funderScience Foundation Ireland, SFI, 16/ERCD/3797-12/RC/2289-P2
dc.contributor.funderFondation pour la Recherche Médicale, FRM, DPA20140629802
dc.contributor.funderMedical Research Foundation, MedResFdn, MRF-058-0014-F-ZHAN-C0866
dc.contributor.funderHorizon Europe funding guarantee, 10041392-785907-945539-10038599
dc.contributor.funderFondation de France, 00081242
dc.contributor.funderEuropean Research Council, ERC, 695313
dc.contributor.funderERA-Net NEURON, NEURON, ANR-18-NEUR00002-01—ADORe-AF12-NEUR0008-01—WM2NA
dc.contributor.funderNational Natural Science Foundation of China, NNSF, 82150710554
dc.date.accessioned2026-05-14T14:50:10Z
dc.date.available2026-05-14T14:50:10Z
dc.date.issued2026-02-25
dc.description.abstractChildhood trauma (CT) is associated with cognitive impairment across major psychiatric disorders. We tested a novel transdiagnostic hypothesis that atypical connectivity of the default mode network (DMN) mediates the association between childhood trauma (CT) and cognitive impairment. The sample of 1851 individuals aged 18-25 included 433 patients with depression, eating disorders, alcohol use disorder, psychosis and ADHD) and were recruited as part of the ESTRA/STRATIFY/IMAGEN studies. CT was measured using the Childhood Trauma Questionnaire (CTQ). The CANTAB spatial working memory task was administered to assess cognition. Four a priori seeds of the default mode network (DMN) were measured during face processing, namely the medial prefrontal cortex (PFC), right lateral parietal (LP), left lateral parietal (LP) and posterior cingulate cortex (PCC), according to the Harvard-Oxford Cortical and Subcortical Atlas (http://www.cma.mgh.harvard.edu/fsl_atlas.html) as implemented in CONN. Patients had significantly reduced DMN connectivity between the four chosen DMN seeds and the rest of the brain. Reduced DMN connectivity mediated the association between higher CT and worse cognitive performance. Our findings are transdiagnostic in nature with stronger effects in some regions observed in depression, and suggest one transdiagnostic cortical network via which CT’s effects on cognition are transmitted.en
dc.description.sponsorshipThis publication has emanated from research supported under the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101034252. Sinead King is supported by a fellowship from the Marie Skłodowska-Curie Actions (101034252). This publication has emanated from research conducted with the financial support of Science Foundation Ireland under Grant No 12/RC/2289-P2, co-funded under the European Regional Development Fund. This work received support from the following sources: the European Union-funded FP6 Integrated Project IMAGEN (Reinforcement-related behaviour in normal brain function and psychopathology) (LSHM-CT- 2007-037286), the Horizon 2020 funded ERC Advanced Grant ‘STRATIFY’ (Brain network based stratification of reinforcement-related disorders) (695313), Horizon Europe ‘environMENTAL’, grant no: 101057429, UK Research and Innovation (UKRI) Horizon Europe funding guarantee (10041392 and 10038599), Human Brain Project (HBP SGA 2, 785907, and HBP SGA 3, 945539), the Chinese government via the Ministry of Science and Technology (MOST). The German Center for Mental Health (DZPG), the Bundesministerium für Bildung und Forschung (BMBF grants 01GS08152
dc.description.sponsorship01EV0711
dc.description.sponsorshipForschungsnetz AERIAL 01EE1406A, 01EE1406B
dc.description.sponsorshipForschungsnetz IMAC-Mind 01GL1745B), the Deutsche Forschungsgemeinschaft (DFG project numbers 186318919 [FOR 1617], 178833530 [SFB 940], 386691645 [NE 1383/14-1], 402170461 [TRR 265], 454245598 [IRTG 2773], 521379614 [TRR 393]), the Medical Research Foundation and Medical Research Council (grants MR/R00465X/1 and MR/S020306/1), the National Institutes of Health (NIH) funded ENIGMA-grants 5U54EB020403-05, 1R56AG058854-01 and U54 EB020403 as well as NIH R01DA049238, the National Institutes of Health, Science Foundation Ireland (16/ERCD/3797). NSFC grant 82150710554. Further support was provided by grants from:—the ANR (ANR-12-SAMA-0004, AAPG2019—GeBra), the Eranet Neuron (AF12-NEUR0008-01—WM2NA
dc.description.sponsorshipand ANR-18-NEUR00002-01—ADORe), the Fondation de France (00081242), the Fondation pour la Recherche Médicale (DPA20140629802), the Mission Interministérielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA), the Assistance-Publique-Hôpitaux-de-Paris and INSERM (interface grant), Paris Sud University IDEX 2012, the Fondation de l’Avenir (grant AP-RM-17-013), the Fédération pour la Recherche sur le Cerveau
dc.description.sponsorshipthe National Institutes of Health, Science Foundation Ireland (16/ERCD/3797), U.S.A. (Axon, Testosterone and Mental Health during Adolescence
dc.description.sponsorshipRO1 MH085772-01A1), and by NIH Consortium grant U54 EB020403, supported by a cross-NIH alliance that funds Big Data to Knowledge Centres of Excellence, the National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) and King’s College London (KCL). Zuo Zhang is supported by a fellowship from the Medical Research Foundation (MRF-058-0014-F-ZHAN-C0866). This paper represents independent research, partly funded by the NIHR Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. This research was reviewed by a team with experience of mental health problems and their carers who have been specially trained to advise on research proposals and documentation through the Young Person’s Mental Health Advisory Group: a free, confidential service in England provided by the National Institute for Health Research Maudsley Biomedical Research Centre via King’s College London.
dc.description.versionPublished Version
dc.format.extent10
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid603
dc.identifier.authororcidKing, S.
dc.identifier.authororcidZhang, Z.
dc.identifier.authororcidRobinson, L.
dc.identifier.authororcidWhelan, R.
dc.identifier.authororcidNees, F.
dc.identifier.authororcidBobou, M.
dc.identifier.authororcidBanaschewski, T.
dc.identifier.authororcidBarker, G.J.
dc.identifier.authororcidBokde, A.L.W.
dc.identifier.authororcidFlor, H.
dc.identifier.authororcidGrigis, A.
dc.identifier.authororcidGaravan, H.
dc.identifier.authororcidGowland, P.
dc.identifier.authororcidHeinz, A.
dc.identifier.authororcidBrühl, R.
dc.identifier.authororcidMartinot, J.-L.
dc.identifier.authororcidMartinot, M.-L.P.
dc.identifier.authororcidArtiges, E.
dc.identifier.authororcidPoustka, L.
dc.identifier.authororcidHohmann, S.
dc.identifier.authororcidHolz, N.
dc.identifier.authororcidBaeuchl, C.
dc.identifier.authororcidSmolka, M.N.
dc.identifier.authororcidVaidya, N.
dc.identifier.authororcidWalter, H.
dc.identifier.authororcidWinterer, J.
dc.identifier.authororcidBroulidakis, M.J.
dc.identifier.authororcidvan Noort, B.M.
dc.identifier.authororcidStringaris, A.
dc.identifier.authororcidZhang, Y.
dc.identifier.authororcidSinclair, J.
dc.identifier.authororcidSchumann, G.
dc.identifier.authororcidSchmidt, U.
dc.identifier.authororcidDesrivières, S.
dc.identifier.authororcidCotter, D.
dc.identifier.authororcidYoung, A.H.
dc.identifier.authororcidDonohoe, G.
dc.identifier.authororcidWolsztynski, E.§0000-0001-9770-9769
dc.identifier.citationKing, S, Zhang, Z, Robinson, L, Whelan, R, Nees, F, Bobou, M, Banaschewski, T, Barker, G J, Bokde, A L W, Flor, H, Grigis, A, Garavan, H, Gowland, P, Heinz, A, Brühl, R, Martinot, J-L, Martinot, M-LP, Artiges, E, Poustka, L, Hohmann, S, Holz, N, Baeuchl, C, Smolka, M N, Vaidya, N, Walter, H, Winterer, J, Broulidakis, M J, van Noort, B M, Stringaris, A, Zhang, Y, Sinclair, J, Schumann, G, Schmidt, U, Desrivières, S, Cotter, D, Young, A H, Donohoe, G & Wolsztynski, E 2026, 'Characterising a stress-sensitive default mode network (DMN) deficit in major psychiatric disorders', Commun. Biolog., vol. 9, no. 1, 603. https://doi.org/10.1038/s42003-025-09400-1
dc.identifier.doi10.1038/s42003-025-09400-1
dc.identifier.issn2399-3642
dc.identifier.issued1
dc.identifier.journaltitleCommun. Biolog.
dc.identifier.otherRIS: urn:68984724C4E135253E0897FF2A3B3C6A
dc.identifier.otherORCID: /0000-0001-9770-9769/work/214724707
dc.identifier.urihttps://hdl.handle.net/10468/18764
dc.identifier.volume9
dc.language.isoen
dc.publisherSpringer Nature
dc.relation.urihttps://www.scopus.com/pages/publications/105037755781
dc.relation.urihttps://www.scopus.com/pages/publications/105037755781?origin=resultslist
dc.rightsPublisher Copyright: © The Author(s) 2026.
dc.rights.accessrightsopen access
dc.rights.licensenameAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.statusPeer reviewed
dc.subjectCANTAB spatial working memory task
dc.subjectChildhood trauma (CT)
dc.subjectCognitive impairment
dc.subjectMajor psychiatric disorders
dc.subject[Insight]
dc.subject[Maths]
dc.titleCharacterising a stress-sensitive default mode network (DMN) deficit in major psychiatric disordersen
dc.typeArticle (peer-reviewed)
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