Gut bacteriophage: Current understanding and challenges

Simple item page
dc.contributor.authorSutton, Thomas D. S.
dc.contributor.authorHill, Colin
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderEuropean Regional Development Funden
dc.contributor.funderJanssen Biotechen
dc.date.accessioned2019-12-10T12:04:59Z
dc.date.available2019-12-10T12:04:59Z
dc.date.issued2019-11-29
dc.description.abstractThe gut microbiome is widely accepted to have a significant impact on human health yet, despite years of research on this complex ecosystem, the contributions of different forces driving microbial population structure remain to be fully elucidated. The viral component of the human gut microbiome is dominated by bacteriophage, which are known to play crucial roles in shaping microbial composition, driving bacterial diversity, and facilitating horizontal gene transfer. Bacteriophage are also one of the most poorly understood components of the human gut microbiome, with the vast majority of viral sequences sharing little to no homology to reference databases. If we are to understand the dynamics of bacteriophage populations, their interaction with the human microbiome and ultimately their influence on human health, we will depend heavily on sequence based approaches and in silico tools. This is complicated by the fact that, as with any research field in its infancy, methods of analyses vary and this can impede our ability to compare the outputs of different studies. Here, we discuss the major findings to date regarding the human virome and reflect on our current understanding of how gut bacteriophage shape the microbiome. We consider whether or not the virome field is built on unstable foundations and if so, how can we provide a solid basis for future experimentation. The virome is a challenging yet crucial piece of the human microbiome puzzle. In order to develop our understanding, we will discuss the need to underpin future studies with robust research methods and suggest some solutions to existing challenges.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid784en
dc.identifier.citationSutton, T. D. S. and Hill, C. (2019) 'Gut Bacteriophage: Current Understanding and Challenges', Frontiers in Endocrinology, 10, 784 (18pp). doi: 10.3389/fendo.2019.00784en
dc.identifier.doi10.3389/fendo.2019.00784en
dc.identifier.eissn1664-2392
dc.identifier.endpage18en
dc.identifier.journaltitleFrontiers in Endocrinologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9381
dc.identifier.volume10en
dc.language.isoenen
dc.publisherFrontiers Mediaen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Spokes Programme/14/SP APC/B3032/IE/Gut Phageomics - Phage as diagnostics and/or therapeutics in IBD/en
dc.rights© 2019, Sutton and Hill. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectViromeen
dc.subjectBacteriophageen
dc.subjectMicrobiomeen
dc.subjectPhage-host interactionsen
dc.subjectMicrobiotaen
dc.titleGut bacteriophage: Current understanding and challengesen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
fendo-10-00784.pdf
Size:
1.7 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download
Thumbnail Image
Name:
Table_1_Gut Bacteriophage_ Current Understanding and Challenges.XLSX
Size:
11.45 KB
Format:
Microsoft Excel XML
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Microbiology - Journal Articles
APC Microbiome Ireland - Journal Articles