Novel insights into the post-translational regulation of an ER localised ubiquitin conjugating enzyme

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Date
2025
Authors
Algoufi, Noor Daifallah
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University College Cork
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Abstract
Ube2J1 is an enzyme that helps cells degrade misfolded proteins at the endoplasmic reticulum. This study shows it is controlled by several signalling pathways, and regulated by previously unidentified mechanisms. Ube2J1 also boosts replication of Vesicular Stomatitis Virus when active. These findings reveal wider roles in stress responses, immunity, and disease.
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ER stress
Citation
Algoufi, N. D. 2025. Novel insights into the post-translational regulation of an ER localised ubiquitin conjugating enzyme. PhD Thesis, University College Cork.
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https://hdl.handle.net/10468/18018
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Research Theses
Analytical & Biological Chemistry Research Facility - Doctoral Theses
Biochemistry and Cell Biology - Doctoral Theses
College of Science, Engineering and Food Science - Doctoral Theses
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© 2025, Noor Algoufi.