Novel insights into the post-translational regulation of an ER localised ubiquitin conjugating enzyme

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dc.check.chapterOfThesiswe wish to redact the entire thesis. no part of the thesis should be made available.en
dc.check.date9999-12-31
dc.contributor.advisorFleming, John V (Eoin)
dc.contributor.authorAlgoufi, Noor Daifallahen
dc.contributor.funderMinistry of Education - Kingdom of Saudi Arabia
dc.contributor.funderUniversity College Cork
dc.date.accessioned2025-10-10T15:31:33Z
dc.date.available2025-10-10T15:31:33Z
dc.date.issued2025
dc.date.submitted2025
dc.description.abstractUbe2J1 is an enzyme that helps cells degrade misfolded proteins at the endoplasmic reticulum. This study shows it is controlled by several signalling pathways, and regulated by previously unidentified mechanisms. Ube2J1 also boosts replication of Vesicular Stomatitis Virus when active. These findings reveal wider roles in stress responses, immunity, and disease.en
dc.description.statusNot peer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAlgoufi, N. D. 2025. Novel insights into the post-translational regulation of an ER localised ubiquitin conjugating enzyme. PhD Thesis, University College Cork.
dc.identifier.endpage221
dc.identifier.urihttps://hdl.handle.net/10468/18018
dc.language.isoenen
dc.publisherUniversity College Corken
dc.relation.projectUniversity College Cork (School of Pharmacy, School of Biochemistry and Cell Biology)
dc.rights© 2025, Noor Algoufi.
dc.subjectER stressen
dc.titleNovel insights into the post-translational regulation of an ER localised ubiquitin conjugating enzymeen
dc.typeDoctoral thesisen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD - Doctor of Philosophyen
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