Porcine feed efficiency-associated intestinal microbiota and physiological traits: finding consistent cross-locational biomarkers for residual feed intake

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dc.contributor.authorMcCormack, Ursula M.
dc.contributor.authorCurião, Tânia
dc.contributor.authorMetzler-Zebeli, Barbara U.
dc.contributor.authorMagowan, Elizabeth
dc.contributor.authorBerry, Donagh P.
dc.contributor.authorReyer, Henry
dc.contributor.authorPrieto, Maria L.
dc.contributor.authorBuzoianu, Stefan G.
dc.contributor.authorHarrison, Michael
dc.contributor.authorRebeiz, Natalie
dc.contributor.authorCrispie, Fiona
dc.contributor.authorCotter, Paul D.
dc.contributor.authorO'Sullivan, Orla
dc.contributor.authorGardiner, Gillian E.
dc.contributor.authorLawlor, Peadar G.
dc.contributor.funderSeventh Framework Programmeen
dc.contributor.funderTeagascen
dc.contributor.funderSociety for Applied Microbiologyen
dc.date.accessioned2019-10-30T06:27:43Z
dc.date.available2019-10-30T06:27:43Z
dc.date.issued2019-06-18
dc.description.abstractOptimal feed efficiency (FE) in pigs is important for economic and environmental reasons. Previous research identified FE-associated bacterial taxa within the intestinal microbiota of growing pigs. This study investigated whether FE-associated bacteria and selected FE-associated physiological traits were consistent across geographic locations (Republic of Ireland [ROI] [two batches of pigs, ROI1 and ROI2], Northern Ireland [NI], and Austria [AT]), where differences in genetic, dietary, and management factors were minimized. Pigs (n = 369) were ranked, within litter, on divergence in residual feed intake (RFI), and 100 extremes were selected (50 with high RFI and 50 with low RFI) across geographic locations for intestinal microbiota analysis using 16S rRNA amplicon sequencing and examination of FE-associated physiological parameters. Microbial diversity varied by geographic location and intestinal sampling site but not by RFI rank, except in ROI2, where more-feed-efficient pigs had greater ileal and cecal diversity. Although none of the 188 RFI-associated taxonomic differences found were common to all locations/batches, Lentisphaerae, Ruminococcaceae, RF16, Mucispirillum, Methanobrevibacter, and two uncultured genera were more abundant within the fecal or cecal microbiota of low-RFI pigs in two geographic locations and/or in both ROI batches. These are major contributors to carbohydrate metabolism, which was reflected in functional predictions. Fecal volatile fatty acids and salivary cortisol were the only physiological parameters that differed between RFI ranks. Despite controlling genetics, diet specification, dietary phases, and management practices in each rearing environment, the rearing environment, encompassing maternal influence, herd health status, as well as other factors, appears to impact intestinal microbiota more than FE.IMPORTANCE Interest in the role of intestinal microbiota in determining FE in pigs has increased in recent years. However, it is not known if the same FE-associated bacteria are found across different rearing environments. In this study, geographic location and intestinal sampling site had a greater influence on the pig gut microbiome than FE. This presents challenges when aiming to identify consistent reliable microbial biomarkers for FE. Nonetheless, seven FE-associated microbial taxa were common across two geographic locations and/or two batches within one location, and these indicated a potentially “healthier” and metabolically more capable microbiota in more-feed-efficient pigs. These taxa could potentially be employed as biomarkers for FE, although bacterial consortia, rather than individual taxa, may be more likely to predict FE. They may also merit consideration for use as probiotics or could be targeted by dietary means as a strategy for improving FE in pigs in the future.en
dc.description.sponsorshipTeagasc (Walsh Fellowship programme); Society for Applied Microbiology (Students into Work grant)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide00324-18en
dc.identifier.citationMcCormack, U.M., Curião, T., Metzler-Zebeli, B.U., Magowan, E., Berry, D.P., Reyer, H., Prieto, M.L., Buzoianu, S.G., Harrison, M., Rebeiz, N. and Crispie, F., 2019. Porcine Feed Efficiency-Associated Intestinal Microbiota and Physiological Traits: Finding Consistent Cross-Locational Biomarkers for Residual Feed Intake. mSystems, 4(4), e00324-18. (19 PP.) DOI:10.1128/mSystems.00324-18en
dc.identifier.doi10.1128/mSystems.00324-18en
dc.identifier.eissn2379-5077
dc.identifier.endpage19en
dc.identifier.issued4en
dc.identifier.journaltitlemSystemsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8921
dc.identifier.volume4en
dc.language.isoenen
dc.publisherAmerican Society for Microbiologyen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/311794/EU/A whole-systems approach to optimising feed efficiency and reducing the ecological footprint of monogastrics/ECO-FCEen
dc.relation.urihttps://msystems.asm.org/content/4/4/e00324-18
dc.rights© 2019 McCormack et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectFeed efficiencyen
dc.subjectGeographic locationen
dc.subjectIntestinal microbiotaen
dc.subjectPigsen
dc.titlePorcine feed efficiency-associated intestinal microbiota and physiological traits: finding consistent cross-locational biomarkers for residual feed intakeen
dc.typeArticle (peer-reviewed)en
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