Liquid lens confocal microscopy with advanced signal processing for higher resolution 3D imaging

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dc.contributor.authorRiza, Nabeel A.
dc.contributor.authorSheikh, Mumtaz A.
dc.contributor.funderEuropean Commissionen
dc.date.accessioned2020-06-02T12:37:44Z
dc.date.available2020-06-02T12:37:44Z
dc.date.issued2009-03-13
dc.description.abstractThe paper first highlights the use of multiple electronically controlled optical lenses, specifically, liquid lenses to realize an axial scanning confocal microscope with potentially less aberrations. Next, proposed is a signal processing method for realizing high resolution three dimensional (3-D) optical imaging using diffraction limited low resolution optical signals. Using axial shift-based signal processing via computer based computation algorithm, three sets of high resolution optical data is determined along the axial (or light beam propagation) direction using low resolution axial data. The three sets of low resolution data are generated by illuminating the 3-D object under observation along its three independent and orthogonal look directions (i.e., x, y, and z) or by physically rotating the object by 90 degrees and also flipping the object by 90 degrees. The three sets of high resolution axial data is combined using a unique mathematical function to interpolate a 3-D image of the test object that is of much higher resolution than the diffraction limited direct measurement 3-D resolution. Confocal microscopy or optical coherence tomography (OCT) are example methods to obtain the axial scan data sets. The proposed processing can be applied to any 3-D wave-based 3-D imager including ones using electromagnetic waves and sound (ultrasonic) waves. Initial computer simulations are described to test the robustness of the proposed high resolution signal processing methoden
dc.description.sponsorshipEuropean Commission (EU 2008 Eramus Mundus Opt-Sci Program)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid725848en
dc.identifier.citationRiza, N. A. and and Sheikh, M. A. (2009) 'Liquid lens confocal microscopy with advanced signal processing for higher resolution 3D imaging', Proceedings of SPIE, 7258, Medical Imaging 2009: Physics of Medical Imaging, 725848, SPIE Medical Imaging, Lake Buena Vista (Orlando Area), Florida, United States, 13 March. doi: 10.1117/12.811338en
dc.identifier.doi10.1117/12.811338en
dc.identifier.eissn1996-756X
dc.identifier.endpage13en
dc.identifier.issn0277-786X
dc.identifier.journaltitleProceedings of SPIEen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/10106
dc.identifier.volume7258en
dc.language.isoenen
dc.publisherSociety of Photo-Optical Instrumentation Engineers (SPIE)en
dc.rights© 2009 Society of Photo-Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.en
dc.subjectImage resolutionen
dc.subjectConfocal microscopyen
dc.subject3D image processingen
dc.subjectMicroscopesen
dc.subjectSignal processingen
dc.subjectOptical resolutionen
dc.subjectDiffractionen
dc.titleLiquid lens confocal microscopy with advanced signal processing for higher resolution 3D imagingen
dc.typeConference itemen
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