Shining a light on intestinal traffic

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dc.contributor.authorMurphy, Carola T.
dc.contributor.authorNally, Kenneth
dc.contributor.authorShanahan, Fergus
dc.contributor.authorMelgar, Silvia
dc.contributor.editorMcCafferty, Donna-Marie
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHigher Education Authorityen
dc.contributor.funderEuropean Commissionen
dc.contributor.funderGlaxoSmithKline, United Kingdomen
dc.date.accessioned2012-07-18T14:25:00Z
dc.date.available2012-07-18T14:25:00Z
dc.date.issued2012-01
dc.date.updated2012-07-18T10:46:07Z
dc.description.abstractInflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, is associated with enhanced leukocyte infiltration to the gut, which is directly linked to the clinical aspects of these disorders. Thus, leukocyte trafficking is a major target for IBD therapy. Past and emerging techniques to study leukocyte trafficking both in vitro and in vivo have expanded our knowledge of the leukocyte migration process and the role of inhibitors. Various strategies have been employed to target chemokine- and integrin-ligand interactions within the multistep adhesion cascade and the S1P/S1PR1 axis in leukocyte migration. Though there is an abundance of preclinical data demonstrating efficacy of leukocyte trafficking inhibitors, many have yet to be confirmed in clinical studies. Vigilance for toxicity and further research is required into this complex and emerging area of IBD therapy.en
dc.description.sponsorshipScience Foundation Ireland (02/CE/B124; 07/CE/B1368)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCarola T. Murphy, Kenneth Nally, Fergus Shanahan, and Silvia Melgar, “Shining a Light on Intestinal Traffic,” Clinical and Developmental Immunology, vol. 2012, Article ID 808157, 14 pages, 2012. doi:10.1155/2012/808157en
dc.identifier.doi10.1155/2012/808157
dc.identifier.issn1740-2522
dc.identifier.issn1740-2530
dc.identifier.journaltitleClinical and Developmental Immunologyen
dc.identifier.startpage808157en
dc.identifier.urihttps://hdl.handle.net/10468/634
dc.identifier.volume2012en
dc.language.isoenen
dc.publisherHindawi Publishing Corporationen
dc.relation.urihttp://www.hindawi.com/journals/cdi/2012/808157/
dc.rightsCopyright © 2012 Carola T. Murphy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en
dc.subjectIBDen
dc.subjectLeukocyte infiltrationen
dc.subjectLeukocyte trafficking inhibitorsen
dc.subject.lcshInflammatory bowel diseases--Treatmenten
dc.subject.lcshGastrointestinal system--Diseasesen
dc.subject.lcshCrohn’s disease--Treatmenten
dc.subject.lcshUlcerative colitis--Treatmenten
dc.subject.lcshLeucocytesen
dc.titleShining a light on intestinal trafficen
dc.typeArticle (peer-reviewed)en
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