Bioaccessibility and cellular uptake of β-carotene encapsulated in model O/W emulsions: influence of initial droplet size and emulsifiers

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dc.contributor.authorLu, Wei
dc.contributor.authorKelly, Alan L.
dc.contributor.authorMiao, Song
dc.contributor.funderNational Natural Science Foundation of China
dc.contributor.funderTeagasc
dc.contributor.funderChina Scholarship Council
dc.date.accessioned2017-12-08T13:33:48Z
dc.date.available2017-12-08T13:33:48Z
dc.date.issued2017-09-20
dc.description.abstractThe effects of the initial emulsion structure (droplet size and emulsifier) on the properties of β-carotene-loaded emulsions and the bioavailability of β-carotene after passing through simulated gastrointestinal tract (GIT) digestion were investigated. Exposure to GIT significantly changed the droplet size, surface charge and composition of all emulsions, and these changes were dependent on their initial droplet size and the emulsifiers used. Whey protein isolate (WPI)-stabilized emulsion showed the highest β-carotene bioaccessibility, while sodium caseinate (SCN)-stabilized emulsion showed the highest cellular uptake of β-carotene. The bioavailability of emulsion-encapsulated β-carotene based on the results of bioaccessibility and cellular uptake showed the same order with the results of cellular uptake being SCN > TW80 > WPI. An inconsistency between the results of bioaccessibility and bioavailability was observed, indicating that the cellular uptake assay is necessary for a reliable evaluation of the bioavailability of emulsion-encapsulated compounds. The findings in this study contribute to a better understanding of the correlation between emulsion structure and the digestive fate of emulsion-encapsulated nutrients, which make it possible to achieve controlled or potential targeted delivery of nutrients by designing the structure of emulsion-based carriersen
dc.description.sponsorshipChina Scholarship Council (No. 201508300001); Teagasc (RMIS6821); National Natural Science Foundation of China (No. 31628016).en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid282
dc.identifier.citationLu, W., Kelly, A. and Miao, S. (2017) 'Bioaccessibility and Cellular Uptake of β-Carotene Encapsulated in Model O/W Emulsions: Influence of Initial Droplet Size and Emulsifiers', Nanomaterials, 7(9), 282 (11pp). doi: 10.3390/nano7090282en
dc.identifier.doi10.3390/nano7090282
dc.identifier.endpage11
dc.identifier.issn2079-4991
dc.identifier.issued9
dc.identifier.journaltitleNanomaterialsen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/5156
dc.identifier.volume7
dc.language.isoenen
dc.publisherMDPIen
dc.relation.urihttp://www.mdpi.com/2079-4991/7/9/282
dc.rights© 2017, the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectEmulsionen
dc.subjectβ-caroteneen
dc.subjectDigestionen
dc.subjectCellular uptakeen
dc.subjectBioavailabilityen
dc.titleBioaccessibility and cellular uptake of β-carotene encapsulated in model O/W emulsions: influence of initial droplet size and emulsifiersen
dc.typeArticle (peer-reviewed)en
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