Microbiota-brain interactions: Moving toward mechanisms in model organisms

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dc.contributor.authorNagpal, Jatin
dc.contributor.authorCryan, John F.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderSaks-Kavanaugh Foundationen
dc.contributor.funderIrish Research Councilen
dc.date.accessioned2022-01-18T12:06:31Z
dc.date.available2022-01-18T12:06:31Z
dc.date.issued2021-10-14
dc.date.updated2022-01-18T11:51:04Z
dc.description.abstractChanges in the microbiota are associated with alterations in nervous system structure-function and behavior and have been implicated in the etiology of neuropsychiatric and neurodegenerative disorders. Most of these studies have centered on mammalian models due to their phylogenetic proximity to humans. Indeed, the germ-free mouse has been a particularly useful model organism for investigating microbiota-brain interactions. However, microbiota-brain axis research on simpler genetic model organisms with a vast and diverse scientific toolkit (zebrafish, Drosophila melanogaster, and Caenorhabditis elegans) is now also coming of age. In this review, we summarize the current state of microbiota-brain axis research in rodents and humans, and then we elaborate and discuss recent research on the neurobiological and behavioral effects of the microbiota in the model systems of fish, flies, and worms. We propose that a cross-species, holistic and mechanistic approach to unravel the microbiota-brain communication is an essential step toward rational microbiota-based therapeutics to combat brain disorders.en
dc.description.sponsorshipScience Foundation Ireland (grant SFI/12/RC/2273_P2); Irish Research Council (Government of Ireland postdoctoral fellowship GOIPD/2019/714)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationNagpal, J. and Cryan, J. F. (2021) 'Microbiota-brain interactions: Moving toward mechanisms in model organisms', Neuron, 109(24), pp.3930-3953. doi: 10.1016/j.neuron.2021.09.036en
dc.identifier.doi10.1016/j.neuron.2021.09.036en
dc.identifier.eissn1097-4199
dc.identifier.endpage3953en
dc.identifier.issn0896-6273
dc.identifier.issued24en
dc.identifier.journaltitleNeuronen
dc.identifier.startpage3930en
dc.identifier.urihttps://hdl.handle.net/10468/12406
dc.identifier.volume109en
dc.language.isoenen
dc.publisherElsevier Inc.en
dc.rights© 2021, Elsevier Inc. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectGut microbiotaen
dc.subjectIntestinal microbiotaen
dc.subjectCommensal bacteriaen
dc.subjectSocial behaviouren
dc.subjectStress responseen
dc.subjectNervous systemen
dc.subjectAnimal modelsen
dc.subjectDrosophilaen
dc.subjectHosten
dc.subjectZebrafishen
dc.titleMicrobiota-brain interactions: Moving toward mechanisms in model organismsen
dc.typeArticle (peer-reviewed)en
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