Varying disease-mediated selection at different life-history stages of Atlantic salmon in fresh water

Simple item page
dc.contributor.authorde Eyto, Elvira
dc.contributor.authorMcGinnity, Philip
dc.contributor.authorHuisman, Jisca
dc.contributor.authorCoughlan, Jamie P.
dc.contributor.authorConsuegra, Sofia
dc.contributor.authorFarrell, Killian
dc.contributor.authorO'Toole, Ciar
dc.contributor.authorTufto, Jarle
dc.contributor.authorMegens, Hendrik-Jan
dc.contributor.authorJordan, William
dc.contributor.authorCross, Thomas F.
dc.contributor.authorStet, René J. M.
dc.contributor.funderFifth Framework Programmeen
dc.contributor.funderMarine Instituteen
dc.date.accessioned2018-03-28T10:53:43Z
dc.date.available2018-03-28T10:53:43Z
dc.date.issued2011-07-04
dc.date.updated2018-03-14T11:58:13Z
dc.description.abstractLaboratory studies on associations between disease resistance and susceptibility and major histocompatibility (MH) genes in Atlantic salmon Salmo salar have shown the importance of immunogenetics in understanding the capacity of populations to fight specific diseases. However, the occurrence and virulence of pathogens may vary spatially and temporally in the wild, making it more complicated to predict the overall effect that MH genes exert on fitness of natural populations and over several life-history stages. Here we show that MH variability is a significant determinant of salmon survival in fresh water, by comparing observed and expected genotype frequencies at MH and control microsatellite loci at parr and migrant stages in the wild. We found that additive allelic effects at immunogenetic loci were more likely to determine survival than dominance deviation, and that selection on certain MH alleles varied with life stage, possibly owing to varying pathogen prevalence and/or virulence over time. Our results highlight the importance of preserving genetic diversity (particularly at MH loci) in wild populations, so that they have the best chance of adapting to new and increased disease challenges as a result of projected climate warming and increasing aquaculture.en
dc.description.sponsorshipFifth Framework Programme (SALIMPACT Q5RS-2001-01185); Marine Institute (Beaufort Marine Research award in Fish Population Genetics)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationde Eyto, E., McGinnity, P., Huisman, J., Coughlan, J., Consuegra, S., Farrell, K., O'Toole, C., Tufto, J., Megens, H.-J., Jordan, W., Cross, T. and Stet, R. J. M. (2011) 'Varying disease-mediated selection at different life-history stages of Atlantic salmon in fresh water', Evolutionary Applications, 4(6), pp. 749-762. doi:10.1111/j.1752-4571.2011.00197.xen
dc.identifier.doi10.1111/j.1752-4571.2011.00197.x
dc.identifier.endpage762en
dc.identifier.issn1752-4571
dc.identifier.issn1752-4563
dc.identifier.issued6en
dc.identifier.journaltitleEvolutionary Applicationsen
dc.identifier.startpage749en
dc.identifier.urihttps://hdl.handle.net/10468/5712
dc.identifier.volume4en
dc.language.isoenen
dc.publisherJohn Wiley & Sons Ltd.en
dc.rights© 2011, the Authors. Evolutionary Applications published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectAtlantic salmonen
dc.subjectFreshwater life stagesen
dc.subjectMajor histocompatibilityen
dc.subjectNatural selectionen
dc.subjectSalmo salaren
dc.subjectSalar L.en
dc.subjectGenetic variationen
dc.subjectPathogen resistanceen
dc.subjectBalancing selectionen
dc.subjectNatural selectionen
dc.subjectWild populationsen
dc.subjectLocal adaptationen
dc.subjectClimate changeen
dc.titleVarying disease-mediated selection at different life-history stages of Atlantic salmon in fresh wateren
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
Eyto_et_al-2011-Evolutionary_Applications.pdf
Size:
732.51 KB
Format:
Adobe Portable Document Format
Description:
Published Version
Download
Thumbnail Image
Name:
eva_197_sm_ts1.xls
Size:
281.5 KB
Format:
Microsoft Excel
Description:
Table S1
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Biological, Earth and Environmental Sciences - Journal Articles