Peripheral tumour targeting using open-source virtual bronchoscopy with electromagnetic tracking: a multi-user pre-clinical study

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dc.contributor.authorJaeger, Herman Alexander
dc.contributor.authorTrauzettel, Fabian
dc.contributor.authorNardelli, Pietro
dc.contributor.authorDaverieux, Federico
dc.contributor.authorHofstad, Erlend Fagertun
dc.contributor.authorLeira, Håkon O.
dc.contributor.authorKennedy, Marcus P.
dc.contributor.authorLangø, Thomas
dc.contributor.authorCantillon-Murphy, Pádraig
dc.contributor.funderEurostarsen
dc.contributor.funderNorges Forskningsråden
dc.contributor.funderRijksdienst voor Ondernemend Nederlanden
dc.contributor.funderEnterprise Irelanden
dc.contributor.funderInstitut de chirurgie guidée par l'Image, Strasbourgen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderNorwegian National Advisory Unit for Ultrasound and Image-Guided Therapyen
dc.contributor.funderNorges Teknisk-Naturvitenskapelige Universiteten
dc.date.accessioned2022-02-02T09:23:34Z
dc.date.available2022-02-02T09:23:34Z
dc.date.issued2018-11-15
dc.date.updated2022-02-02T08:49:05Z
dc.description.abstractObjectives: The goal was to demonstrate the utility of open-source tracking and visualisation tools in the targeting of lung cancer. Material and methods: The study demonstrates the first deployment of the Anser electromagnetic (EM) tracking system with the CustusX image-guided interventional research platform to navigate using an endobronchial catheter to injected tumour targets. Live animal investigations validated the deployment and targeting of peripheral tumour models using an innovative tumour marking routine. Results: Novel tumour model deployment was successfully achieved at all eight target sites across two live animal investigations without pneumothorax. Virtual bronchoscopy with tracking successfully guided the tracked catheter to 2–12 mm from the target tumour site. Deployment of a novel marker was achieved at all eight sites providing a reliable measure of targeting accuracy. Targeting accuracy within 10 mm was achieved in 7/8 sites and in all cases, the virtual target distance at marker deployment was within the range subsequently measured with x-ray. Conclusions: Endobronchial targeting of peripheral airway targets is feasible using existing open-source technology. Notwithstanding the shortcomings of current commercial platforms, technological improvements in EM tracking and registration accuracy fostered by open-source technology may provide the impetus for widespread clinical uptake of electromagnetic navigation in bronchoscopy.en
dc.description.sponsorshipEurostars (Eureka project number 11581, entitled ‘MARIANA – Image-guided catheter navigation in the outer airways')en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationJaeger, H. A.,Trauzettel, F., Nardelli, P., Daverieux, F., Hofstad, E. F., Leira, H. O., Kennedy, M. P., Langø, T. and Cantillon-Murphy, P. (2018) 'Peripheral tumour targeting using open-source virtual bronchoscopy with electromagnetic tracking: a multi-user pre-clinical study', Minimally Invasive Therapy and Allied Technologies, 28(6), pp. 363-372. doi: 10.1080/13645706.2018.1544911en
dc.identifier.doi10.1080/13645706.2018.1544911en
dc.identifier.endpage372en
dc.identifier.issn1364-5706
dc.identifier.issn1365-2931
dc.identifier.issued6en
dc.identifier.journaltitleMinimally Invasive Therapy and Allied Technologiesen
dc.identifier.startpage363en
dc.identifier.urihttps://hdl.handle.net/10468/12516
dc.identifier.volume28en
dc.language.isoenen
dc.publisherTaylor & Francisen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/15/TIDA/2846/IE/Early detection of lung cancer through novel endoscopic technology/en
dc.rights© 2018, Society of Medical Innovation and Technology. Published by Taylor & Francis. All rights reserved. This is an Accepted Manuscript of an article published by Taylor & Francis on 15 November 2018 in Minimally Invasive Therapy & Allied Technologies, available online: https://doi.org/10.1080/13645706.2018.1544911en
dc.subjectLung canceren
dc.subjectTumouren
dc.subjectBronchoscopyen
dc.subjectElectromagnetic navigationen
dc.subjectElectromagnetic trackingen
dc.subjectVirtual biopsyen
dc.subjectOpen-sourceen
dc.titlePeripheral tumour targeting using open-source virtual bronchoscopy with electromagnetic tracking: a multi-user pre-clinical studyen
dc.typeArticle (peer-reviewed)en
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