Healthcare professionals’ perspectives on use of PCSK9 inhibitors in cardiovascular disease: an in-depth qualitative study

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dc.contributor.authorLee, Geraldine A.en
dc.contributor.authorDurante, Angelaen
dc.contributor.authorBaker, Edward E.en
dc.contributor.authorVellone, Ercoleen
dc.contributor.authorCaggianelli, Gabrieleen
dc.contributor.authorDellafiore, Federicaen
dc.contributor.authorKhan, Mutibaen
dc.contributor.authorKhatib, Ranien
dc.contributor.funderEuropean Society of Cardiologyen
dc.contributor.funderAmgenen
dc.contributor.funderNovo Nordisken
dc.date.accessioned2024-05-28T11:39:04Z
dc.date.available2024-05-28T11:39:04Z
dc.date.issued2024-05-24en
dc.description.abstractAim: Injectable medicines such as PCSK-9 inhibitors are increasingly used to manage risk factors for cardiovascular events with little information around the perceptions of healthcare professionals (HCPs) on the administrative and clinical practicalities. The aim was to identify the facilitators and barriers on the use of injectable therapies with CV benefits through interviews with HCPs. Methods and results: Qualitative interviews were conducted in the United Kingdom (London and Leeds) and Italy (Rome and Milan) in 2021. Coding was undertaken using NVivo and thematic analysis performed. A total of 38 HCPs were interviewed, 19 in each country composing of physicians (n = 18), pharmacists (n = 10), nurses (n = 9) and pharmacy technician (n = 1). Four themes emerged: (i) Clinicians’ previous experiences with injectable therapies (ii) Challenges with patients’ behaviours and beliefs (iii) Clinicians’ knowledge of injectable therapies and therapeutic inertia and (iv) Organisational and governance issues. The behaviour and beliefs from healthcare professionals focused on facilitating behaviour change as well as the poor interdisciplinary working and collaboration. Therapeutic inertia was raised where physicians either lacked awareness of injectable therapies or were unwilling to prescribe them. The importance of facilitating patient education on injection techniques was highlighted while organisational and governance issues identified the lack of guidance to inform practice. Clear pathways are required to identify those who were eligible for injectable therapies as well as on how injectables should be prescribed. Conclusion: If medicine optimisation is to be achieved, there needs to be structured processes in place to identify eligible patients and the development of educational material.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleidzvae081en
dc.identifier.citationLee, G.A., Durante, A., Baker, E.E., Vellone, E., Caggianelli, G., Dellafiore, F., Khan, M. and Khatib, R. (2024) 'Healthcare professionals’ perspectives on use of PCSK9 inhibitors in cardiovascular disease: an in-depth qualitative study', European Journal of Cardiovascular Nursing, zvae081. https://doi.org/10.1093/eurjcn/zvae081en
dc.identifier.doihttps://doi.org/10.1093/eurjcn/zvae081en
dc.identifier.eissn1873-1953en
dc.identifier.issn1474-5151en
dc.identifier.journaltitleEuropean Journal of Cardiovascular Nursingen
dc.identifier.urihttps://hdl.handle.net/10468/15927
dc.language.isoenen
dc.publisherOxford University Pressen
dc.rights© 2024, the Authors. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. en
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectInjectable therapiesen
dc.subjectCardiovascular diseaseen
dc.subjectDyslipidemiaen
dc.subjectHealthcare professionalsen
dc.titleHealthcare professionals’ perspectives on use of PCSK9 inhibitors in cardiovascular disease: an in-depth qualitative studyen
dc.typeArticle (peer-reviewed)en
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