Human skin microbiota is a rich source of bacteriocin-producing staphylococci that kill human pathogens

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dc.contributor.authorO'Sullivan, Julie N.
dc.contributor.authorRea, Mary C.
dc.contributor.authorO'Connor, Paula M.
dc.contributor.authorHill, Colin
dc.contributor.authorRoss, R. Paul
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2019-11-26T05:50:47Z
dc.date.available2019-11-26T05:50:47Z
dc.date.issued2018-12-24
dc.description.abstractThe demand for novel antimicrobial therapies due to the threat posed by antimicrobial resistance has resulted in a growing interest in the protective role of our skin bacteria and the importance of competition among bacteria on the skin. A survey of the cultivable bacteria on human skin was undertaken to identify the capacity of the skin microbiota to produce bacteriocins with activity against skin pathogens. Twenty-one bacteriocins produced by bacteria isolated from seven sites on the human body of each subject exhibited inhibition spectra ranging from broad to narrow range, inhibiting many Gram-positive bacteria, including opportunistic skin pathogens such as Propionibacterium acnes (recently renamed Cutibacterium acnes), Staphylococcus epidermidis and methicillin-resistant Staphylococcus aureus (MRSA). Sequencing indicated that the antimicrobial-producing isolates were predominately species/strains of the Staphylococcus genus. Colony mass spectrometry revealed peptide masses that do not correspond to known bacteriocins. In an era where antibiotic resistance is of major concern, the inhibitory effect of novel bacteriocins from the bacteria of skin origin demonstrates the antimicrobial potential that could be harnessed from within the human skin microbiota.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleidfiy241en
dc.identifier.citationO'Sullivan, J.N., Rea, M.C., O'Connor, P.M., Hill, C. and Ross, R.P. (2018) 'Human skin microbiota is a rich source of bacteriocin-producing staphylococci that kill human pathogens'. FEMS microbiology ecology, 95(2), fiy241. (10pp). doi:10.1093/femsec/fiy241en
dc.identifier.doi10.1093/femsec/fiy241en
dc.identifier.eissn1574-6941
dc.identifier.endpage10en
dc.identifier.issn0168-6496
dc.identifier.issued2en
dc.identifier.journaltitleFEMS Microbiology Ecologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9228
dc.identifier.volume95en
dc.language.isoenen
dc.publisherFEMSen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.urihttps://academic.oup.com/femsec/article/95/2/fiy241/5259109
dc.rights© 2019 Oxford University Press. © FEMS 2018. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.comen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectSkin pathogensen
dc.subjectStaphylococcien
dc.subjectAntimicrobial potentialen
dc.subjectBacteriocinen
dc.subjectSkin microbiotaen
dc.subjectSkin microbiomeen
dc.titleHuman skin microbiota is a rich source of bacteriocin-producing staphylococci that kill human pathogensen
dc.typeArticle (peer-reviewed)en
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