Sulfonamide-based diffusible signal factor analogs interfere with quorum sensing in Stenotrophomonas maltophilia and Burkholderia cepacia

Simple item page
dc.contributor.authorHuedo, Pol
dc.contributor.authorKumar, Vydyula P.
dc.contributor.authorHorgan, Conor
dc.contributor.authorYero, Daniel
dc.contributor.authorDaura, Xavier
dc.contributor.authorGibert, Isidre
dc.contributor.authorO'Sullivan, Timothy P.
dc.contributor.funderIrish Research Councilen
dc.contributor.funderMinisterio de Ciencia e Innovaciónen
dc.contributor.funderAgència de Gestió d'Ajuts Universitaris i de Recercaen
dc.contributor.funderHorizon 2020en
dc.date.accessioned2021-08-17T15:15:02Z
dc.date.available2021-08-17T15:15:02Z
dc.date.issued2019-08-30
dc.date.updated2021-08-17T11:55:06Z
dc.description.abstractAim: Stenotrophomonas maltophilia (Sm) and Burkholderia cepacia complex (BCC) are Gram-negative bacterial pathogens, which are typically multidrug resistant and excellent biofilm producers. These phenotypes are controlled by quorum sensing (QS) systems from the diffusible signal factor (DSF) family. We aim to interfere with this QS system as an alternative approach in combatting such difficult-to-treat infections. Materials & methods: A library of sulfonamide-based DSF bioisosteres was synthesized and tested against the major phenotypes regulated by QS. Results & conclusion: Several analogs display significant antibiofilm activity while the majority increase the action of the last-resort antibiotic colistin against Sm and BCC. Most compounds inhibit DSF synthesis in the Sm K279a strain. Our results support the strategy of interfering with QS communications to combat multidrug resistance.en
dc.description.sponsorshipMinisterio de Ciencia e Innovación (BIO2015-66674-R); Agència de Gestió d'Ajuts Universitaris i de Recerca (2014-SGR-1280); Irish Research Council (Government of Ireland Postgraduate Research Scholarship GOIPG/2017/1111)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHuedo, P., Kumar, V. P., Horgan, C., Yero, D., Daura, X., Gibert, I. and O'Sullivan, T. P. (2019) 'Sulfonamide-based diffusible signal factor analogs interfere with quorum sensing in Stenotrophomonas maltophilia and Burkholderia cepacia', Future Medicinal Chemistry, 11(13), pp. 1565-1582. doi: 10.4155/fmc-2019-0015en
dc.identifier.doi10.4155/fmc-2019-0015en
dc.identifier.eissn1756-8927
dc.identifier.endpage1582en
dc.identifier.issn1756-8919
dc.identifier.issued13en
dc.identifier.journaltitleFuture Medicinal Chemistryen
dc.identifier.startpage1565en
dc.identifier.urihttps://hdl.handle.net/10468/11750
dc.identifier.volume11en
dc.language.isoenen
dc.publisherFuture Science Groupen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-IF-EF-ST/655508/EU/COMMANDEER: Disrupting microbial resistance using rationally designed signalling molecules/COMMANDEERen
dc.rights© 2019, Future Science Group. All rights reserved.en
dc.subjectAntimicrobialsen
dc.subjectBiofilmsen
dc.subjectBioisosterismen
dc.subjectBurkholderia cepacia complexen
dc.subjectMulti drug resistanceen
dc.subjectNosocomial pathogensen
dc.subjectQuorum sensing (QS)en
dc.subjectQS inhibitorsen
dc.subjectStenotrophomonas maltophiliaen
dc.subjectSulfonamidesen
dc.titleSulfonamide-based diffusible signal factor analogs interfere with quorum sensing in Stenotrophomonas maltophilia and Burkholderia cepaciaen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
FMC_Author_Archive.pdf
Size:
612.07 KB
Format:
Adobe Portable Document Format
Description:
Accepted Version
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Chemistry - Journal Articles
Analytical & Biological Chemistry Research Facility - Journal Articles
Pharmacy - Journal Articles