RNA phage biology in a metagenomic era

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dc.contributor.authorCallanan, Julie
dc.contributor.authorStockdale, Stephen R.
dc.contributor.authorShkoporov, Andrey N.
dc.contributor.authorDraper, Lorraine A.
dc.contributor.authorRoss, R. Paul
dc.contributor.authorHill, Colin
dc.contributor.funderScience Foundation Ireland
dc.date.accessioned2018-09-27T12:08:20Z
dc.date.available2018-09-27T12:08:20Z
dc.date.issued2018
dc.description.abstractThe number of novel bacteriophage sequences has expanded significantly as a result of many metagenomic studies of phage populations in diverse environments. Most of these novel sequences bear little or no homology to existing databases (referred to as the “viral dark matter”). Also, these sequences are primarily derived from DNA-encoded bacteriophages (phages) with few RNA phages included. Despite the rapid advancements in high-throughput sequencing, few studies enrich for RNA viruses, i.e., target viral rather than cellular fraction and/or RNA rather than DNA via a reverse transcriptase step, in an attempt to capture the RNA viruses present in a microbial communities. It is timely to compile existing and relevant information about RNA phages to provide an insight into many of their important biological features, which should aid in sequence-based discovery and in their subsequent annotation. Without comprehensive studies, the biological significance of RNA phages has been largely ignored. Future bacteriophage studies should be adapted to ensure they are properly represented in phageomic studies.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid386
dc.identifier.citationCallanan, J., Stockdale, S., Shkoporov, A., Draper, L., Ross, R. and Hill, C. (2018) 'RNA phage biology in a metagenomic era', Viruses, 10(7), 386 (17pp). doi: 10.3390/v10070386en
dc.identifier.doi10.3390/v10070386
dc.identifier.endpage17
dc.identifier.issn1999-4915
dc.identifier.issued7
dc.identifier.journaltitleVirusesen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/6937
dc.identifier.volume10
dc.language.isoenen
dc.publisherMDPIen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/
dc.relation.urihttp://www.mdpi.com/1999-4915/10/7/386
dc.rights© 2018, the Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBacteriophageen
dc.subjectRna virusesen
dc.subjectRnaen
dc.subjectCystoviridaeen
dc.subjectLeviviridaeen
dc.titleRNA phage biology in a metagenomic eraen
dc.typeArticle (peer-reviewed)en
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