The impact of maternal inflammatory conditions during pregnancy on the risk of autism: methodological challenges

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dc.contributor.authorKhashan, Ali S.en
dc.contributor.authorO'Keeffe, Gerard W.en
dc.date.accessioned2024-05-13T14:53:16Z
dc.date.available2024-05-13T14:53:16Z
dc.date.issued2024-10-11en
dc.description.abstractIn the current issue of Biological Psychiatry: Global Open Science, Croen et al. (1) report the results of a case-control study that examined the association between inflammatory conditions during pregnancy and the risk of autism spectrum disorder (ASD) and other neurodevelopmental disorders. They proposed that maternal inflammation during pregnancy stemming from immune or metabolic dysregulation would adversely impact ASD risk, and that individual and combinations of maternal conditions may lead to different outcomes in offspring. They found that maternal asthma (odds ratio [OR] = 1.62 [95% CI, 1.15–2.29]) and obesity (OR = 1.51 [95% CI, 1.07–2.13]) are associated with a higher risk of ASD in offspring. Strikingly, the combination of asthma and extreme obesity had the greatest odds of ASD (OR = 16.9 [95% CI, 5.13–55.71]), among female children only. This suggests that while individual maternal conditions can impact a child’s risk of ASD, the combination of certain maternal conditions may have a significantly greater impact on this risk than either condition alone. Refers to: Inflammatory Conditions During Pregnancy and Risk of Autism and Other Neurodevelopmental Disorders Biological Psychiatry Global Open Science, Volume 4, Issue 1, January 2024, Pages 39-50 Lisa A. Croen, Jennifer L. Ames, Yinge Qian, Stacey Alexeeff, Paul Ashwood, Erica P. Gunderson, Yvonne W. Wu, Andrew S. Boghossian, Robert Yolken, Judy Van de Water, Lauren A. Weiss. https://doi.org/10.1016/j.bpsgos.2023.09.008en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid100287en
dc.identifier.citationKhashan, A.S. and O’Keeffe, G.W. (2024) ‘The impact of maternal inflammatory conditions during pregnancy on the risk of autism: methodological challenges’, Biological Psychiatry Global Open Science, 4(2), 100287 (2 pp). Available at: https://doi.org/10.1016/j.bpsgos.2023.100287.en
dc.identifier.doihttps://doi.org/10.1016/j.bpsgos.2023.100287en
dc.identifier.endpage2en
dc.identifier.issn2667-1743en
dc.identifier.issued2en
dc.identifier.journaltitleBiological Psychiatry Global Open Scienceen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/15858
dc.identifier.volume4en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.ispartofBiological Psychiatry Global Open Scienceen
dc.rights© 2023 The Authors. Published by Elsevier Inc on behalf of the Society of Biological Psychiatry. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectPregnancyen
dc.subjectRisk factorsen
dc.subjectCausal associationsen
dc.subjectOutcomesen
dc.titleThe impact of maternal inflammatory conditions during pregnancy on the risk of autism: methodological challengesen
dc.typeArticle (peer-reviewed)en
oaire.citation.issue2en
oaire.citation.volume4en
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