Computed tomography dose optimisation in cystic fibrosis: A review.

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Ferris, Helena
Twomey, Maria
Moloney, Fiachra
O'Neill, Siobhán B.
Murphy, Kevin P.
O'Connor, Owen J.
Maher, Michael M.
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Baishideng Publishing Group
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Cystic fibrosis (CF) is the most common autosomal recessive disease of the Caucasian population worldwide, with respiratory disease remaining the most relevant source of morbidity and mortality. Computed tomography (CT) is frequently used for monitoring disease complications and progression. Over the last fifteen years there has been a six-fold increase in the use of CT, which has lead to a growing concern in relation to cumulative radiation exposure. The challenge to the medical profession is to identify dose reduction strategies that meet acceptable image quality, but fulfil the requirements of a diagnostic quality CT. Dose-optimisation, particularly in CT, is essential as it reduces the chances of patients receiving cumulative radiation doses in excess of 100 mSv, a dose deemed significant by the United Nations Scientific Committee on the Effects of Atomic Radiation. This review article explores the current trends in imaging in CF with particular emphasis on new developments in dose optimisation.
Cystic fibrosis , Dose optimization , Computed tomography , Dose , Ionising radiation , Kalydeco , low dose CT , CT dose reduction
Ferris, H., Twomey, M., Moloney, F., O’Neill, S. B., Murphy, K. P., O’Connor, O. J. and Maher, M. M. (2016) 'Computed tomography dose optimisation in cystic fibrosis: A review', World Journal of Radiology: WJR, 8(4) pp. 331-341. doi:10.4329/wjr.v8.i4.331