Integrated (meta) genomic and synthetic biology approaches to develop new biocatalysts

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dc.contributor.authorParages, María L.
dc.contributor.authorGutiérrez-Barranquero, José A.
dc.contributor.authorReen, F. Jerry
dc.contributor.authorDobson, Alan D. W.
dc.contributor.authorO'Gara, Fergal
dc.contributor.funderSeventh Framework Programmeen
dc.contributor.funderHorizon 2020en
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderDepartment of Agriculture, Food and the Marineen
dc.contributor.funderFood Institutional Research Measureen
dc.contributor.funderIrish Research Council for Science, Engineering and Technologyen
dc.contributor.funderHealth Research Boarden
dc.contributor.funderIrish Thoracic Societyen
dc.contributor.funderMarine Instituteen
dc.contributor.funderTeagascen
dc.date.accessioned2019-10-23T14:49:20Z
dc.date.available2019-10-23T14:49:20Z
dc.date.issued2016-03-21
dc.date.updated2019-10-23T14:32:49Z
dc.description.abstractIn recent years, the marine environment has been the subject of increasing attention from biotechnological and pharmaceutical industries as a valuable and promising source of novel bioactive compounds. Marine biodiscovery programmes have begun to reveal the extent of novel compounds encoded within the enormous bacterial richness and diversity of the marine ecosystem. A combination of unique physicochemical properties and spatial niche-specific substrates, in wide-ranging and extreme habitats, underscores the potential of the marine environment to deliver on functionally novel biocatalytic activities. With the growing need for green alternatives to industrial processes, and the unique transformations which nature is capable of performing, marine biocatalysts have the potential to markedly improve current industrial pipelines. Furthermore, biocatalysts are known to possess chiral selectivity and specificity, a key focus of pharmaceutical drug design. In this review, we discuss how the explosion in genomics based sequence analysis, allied with parallel developments in synthetic and molecular biology, have the potential to fast-track the discovery and subsequent improvement of a new generation of marine biocatalysts.en
dc.description.sponsorshipDepartment of Agriculture and Food (FIRM/RSF/CoFoRD; FIRM 08/RDC/629; FIRM 1/F009/MabS; FIRM 13/F/516); Irish Research Council for Science, Engineering and Technology (PD/2011/2414; GOIPG/2014/647); Health Research Board/Irish Thoracic Society (MRCG-2014-6); Marine Institute (Beaufort award C2CRA 2007/082); Teagasc (Walsh Fellowship 2013)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid62en
dc.identifier.citationParages, M. L., Gutiérrez-Barranquero, J. A., Reen, F. J., Dobson, A. D. W. and O’Gara, F. (2016) 'Integrated (Meta) Genomic and Synthetic Biology Approaches to Develop New Biocatalysts', Marine Drugs, 14(3), 62 (29 pp). doi: 10.3390/md14030062en
dc.identifier.doi10.3390/md14030062en
dc.identifier.endpage29en
dc.identifier.issn1660-3397
dc.identifier.issued3en
dc.identifier.journaltitleMarine Drugsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8850
dc.identifier.volume14en
dc.language.isoenen
dc.publisherMDPIen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP3::PEOPLE/607786/EU/BluePharmTrain/BLUEPHARMTRAINen
dc.relation.projectinfo:eu-repo/grantAgreement/FCT/SFRH::Investigação/SFRH/BI/52146/2013/PT/MARIE CURIE INITIAL TRAINING NETWORK (FP7-PEOPLE-2011-ITN;en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/312184/EU/Increasing Value and Flow in the Marine Biodiscovery Pipeline/PHARMASEAen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/311975/EU/Marine Microorganisms: Cultivation Methods for Improving their Biotechnological Applications/MACUMBAen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/287589/EU/Marine Microbial Biodiversity, Bioinformatics and Biotechnology/MICRO B3en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP3::PEOPLE/256596/EU/Dissecting the role of a novel transcriptional regulator in microbial-host interactomes./MEXT REGULATIONen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::IA/634486/EU/Industrial Applications of Marine Enzymes: Innovative screening and expression platforms to discover and use the functional protein diversity from the sea/INMAREen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2275/IE/Synthesis and Solid State Pharmaceutical Centre (SSPC)/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/13/TIDA/B2625/IE/Small molecule inhibitors of HIF-1: a new class of anti-cancer therapeutics./en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/12/TIDA/B2411/IE/Development of small molecule therapeutics for medical intervention: anti-biofilm inhibitors for the medical device sector./en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/12/TIDA/B2405/IE/Optimised detection of key biomarkers of Pseudomonas aeruginosa towards a clinical application/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/14/TIDA/2438/IE/Next Generation Antibiotics: anti-biofilm, anti-pathogenic natural bioactives from marine microorganisms./en
dc.relation.urihttps://www.mdpi.com/1660-3397/14/3/62
dc.rights© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/)en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectSynthetic biologyen
dc.subjectMetagenomicsen
dc.subjectBiocatalysisen
dc.subjectMarineen
dc.subjectBiodiscoveryen
dc.subjectChassisen
dc.subjectVectoren
dc.subjectHeterologous expressionen
dc.titleIntegrated (meta) genomic and synthetic biology approaches to develop new biocatalystsen
dc.typeArticle (peer-reviewed)en
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