The impact of riluzole on neurobehavioral outcomes in preclinical models of traumatic and nontraumatic spinal cord injury: results from a systematic review of the literature

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dc.contributor.authorTetreault, Lindsay A.
dc.contributor.authorZhu, Mary P.
dc.contributor.authorWilson, Jefferson R.
dc.contributor.authorKaradimas, Spyridon K.
dc.contributor.authorFehlings, Michael G.
dc.date.accessioned2019-11-20T05:15:36Z
dc.date.available2019-11-20T05:15:36Z
dc.date.issued2019-05-12
dc.description.abstractStudy Design:Systematic review.Objective:To evaluate the impact of riluzole on neurobehavioral outcomes in preclinical models of nontraumatic and traumatic spinal cord injury (SCI).Methods:An extensive search of the literature was conducted in Medline, EMBASE, and Medline in Process. Studies were included if they evaluated the impact of riluzole on neurobehavioral outcomes in preclinical models of nontraumatic and traumatic SCI. Extensive data were extracted from relevant studies, including sample characteristics, injury model, outcomes assessed, timing of evaluation, and main results. The SYRCLE checklist was used to assess various sources of bias.Results:The search yielded a total of 3180 unique citations. A total of 16 studies were deemed relevant and were summarized in this review. Sample sizes ranged from 14 to 90, and injury models included traumatic SCI (n = 9), degenerative cervical myelopathy (n = 2), and spinal cord-ischemia (n = 5). The most commonly assessed outcome measures were BBB (Basso, Beattie, Besnahan) locomotor score and von Frey filament testing. In general, rats treated with riluzole exhibited significantly higher BBB locomotor scores than controls. Furthermore, riluzole significantly increased withdrawal thresholds to innocuous stimuli and tail flick latency following application of radiant heat stimuli. Finally, rats treated with riluzole achieved superior results on many components of gait assessment.Conclusion:In preclinical models of traumatic and nontraumatic SCI, riluzole significantly improves locomotor scores, gait function, and neuropathic pain. This review provides the background information necessary to interpret the results of clinical trials on the impact of riluzole in traumatic and nontraumatic SCI.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid2192568219835516en
dc.identifier.citationTetreault, L.A., Zhu, M.P., Wilson, J.R., Karadimas, S.K. and Fehlings, M.G. (2019) 'The Impact of Riluzole on Neurobehavioral Outcomes in Preclinical Models of Traumatic and Nontraumatic Spinal Cord Injury: Results From a Systematic Review of the Literature'. Global Spine Journal, 2192568219835516. (14pp). DOI:10.1177/2192568219835516en
dc.identifier.doi10.1177/2192568219835516en
dc.identifier.eissn2192-5690
dc.identifier.endpage14en
dc.identifier.issn2192-5682
dc.identifier.journaltitleGlobal Spine Journalen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9112
dc.language.isoenen
dc.publisherSAGE Publications Inc.en
dc.relation.urihttps://journals.sagepub.com/doi/10.1177/2192568219835516
dc.rights© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 License (http://www.creativecommons.org/licenses/by-nc-nd/4.0/) which permits non-commercial use, reproduction and distribution of the work as published without adaptation or alteration, without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectRiluzoleen
dc.subjectSpinal cord injuryen
dc.subjectReviewen
dc.subjectDegenerative cervical myelopathyen
dc.subjectLocomotor scoresen
dc.subjectNeuropathic painen
dc.titleThe impact of riluzole on neurobehavioral outcomes in preclinical models of traumatic and nontraumatic spinal cord injury: results from a systematic review of the literatureen
dc.typeArticle (peer-reviewed)en
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