A role for the orphan nuclear receptor TLX in the interaction between neural precursor cells and microglia

Simple item page
dc.contributor.authorKozareva, Danka A.
dc.contributor.authorMoloney, Gerard M.
dc.contributor.authorHoban, Alan E.
dc.contributor.authorRossini, Valerio
dc.contributor.authorNally, Ken
dc.contributor.authorCryan, John F.
dc.contributor.authorNolan, Yvonne M.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2019-11-19T10:07:00Z
dc.date.available2019-11-19T10:07:00Z
dc.date.issued2019-02-22
dc.description.abstractMicroglia are an essential component of the neurogenic niche in the adult hippocampus and are involved in the control of neural precursor cell (NPC) proliferation, differentiation and the survival and integration of newborn neurons in hippocampal circuitry. Microglial and neuronal cross-talk is mediated in part by the chemokine fractalkine/chemokine (C-X3-C motif) ligand 1 (CX3CL1) released from neurons, and its receptor CX3C chemokine receptor 1 (CX3CR1) which is expressed on microglia. A disruption in this pathway has been associated with impaired neurogenesis yet the specific molecular mechanisms by which this interaction occurs remain unclear. The orphan nuclear receptor TLX (Nr2e1; homologue of the Drosophila tailless gene) is a key regulator of hippocampal neurogenesis, and we have shown that in its absence microglia exhibit a pro-inflammatory activation phenotype. However, it is unclear whether a disturbance in CX3CL1/CX3CR1 communication mediates an impairment in TLX-related pathways which may have subsequent effects on neurogenesis. To this end, we assessed miRNA expression of up- and down-stream signalling molecules of TLX in the hippocampus of mice lacking CX3CR1. Our results demonstrate that a lack of CX3CR1 is associated with altered expression of TLX and its downstream targets in the hippocampus without significantly affecting upstream regulators of TLX. Thus, TLX may be a potential participant in neural stem cell (NSC)–microglial cross-talk and may be an important target in understanding inflammatory-associated impairments in neurogenesis.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleidNS20180177en
dc.identifier.citationKozareva, D.A., Moloney, G.M., Hoban, A.E., Rossini, V., Nally, K., Cryan, J.F. and Nolan, Y., 2019. A role for the orphan nuclear receptor TLX in the interaction between neural precursor cells and microglia. Neuronal Signaling, (NS20180177). DOI:10.1042/NS20180177en
dc.identifier.doi10.1042/NS20180177en
dc.identifier.eissn2059-6553
dc.identifier.endpage12en
dc.identifier.issued1en
dc.identifier.journaltitleNeuronal Signalingen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9030
dc.identifier.volume3en
dc.language.isoenen
dc.publisherPortland Pressen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Investigator Programme/12/IA/1537/IE/The nuclear receptor TLX as a cell intrinsic regulator underlying inflammation and stress-induced changes in hippocampal neurogenesis: relevance to cognitive disorders/en
dc.relation.urihttp://www.neuronalsignaling.org/content/3/1/NS20180177
dc.rights© 2019 The Author(s)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectMicrogliaen
dc.subjectAdult hippocampusen
dc.subjectNeural precursor cell (NPC)en
dc.subjectNewborn neuronsen
dc.subjectHippocampal circuitryen
dc.titleA role for the orphan nuclear receptor TLX in the interaction between neural precursor cells and microgliaen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
NS20180177.full.pdf
Size:
1.8 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Anatomy and Neuroscience - Journal Articles
APC Microbiome Ireland - Journal Articles
Biochemistry and Cell Biology - Journal Articles