Oxidative stress in pre-eclampsia; have we been looking in the wrong place?

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dc.check.date2018-01-18
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorWilliamson, Rachel D.
dc.contributor.authorMcCarthy, Cathal
dc.contributor.authorMcCarthy, Fergus P.
dc.contributor.authorKenny, Louise C.
dc.date.accessioned2017-12-20T12:22:02Z
dc.date.available2017-12-20T12:22:02Z
dc.date.issued2017-01-18
dc.date.updated2017-12-20T12:14:15Z
dc.description.abstractPre-eclampsia is a disorder of late pregnancy. It is a major cause of maternal and perinatal morbidity and mortality, accounting for nearly 18% of all maternal deaths worldwide; an estimated 77,000 maternal deaths per year [1]. Poor placentation is considered to be an initial cause of the placental ischemia [2]. Placental ischemia in turn gives rise to oxidative stress in the placenta and leads to shedding of syncytiotrophoblast debris into the maternal circulation provoking a systemic maternal inflammatory response and release of sFLT and sENG causing maternal vascular endothelial dysfunction. The ubiquitous nature of the maternal vascular endothelium accounts for the diverse multi-system nature of pre-eclampsia. Currently there is no treatment for pre-eclampsia except delivery of the placenta and the baby, with the attendant risk of iatrogenic prematurity and significant neonatal morbidity and mortality. As a result, intensive research endeavours have focused on defining the molecular mechanisms of pre-eclampsia and the identification of new pre-symptomatic biomarkers of the condition. This review focuses on the role of elevated oxidative stress in the pathology of pre-eclampsia and potential therapeutic agents targeting oxidative stress that may prevent or ameliorate this disorder.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationWilliamson, R. D., McCarthy, C., McCarthy, F. P. and Kenny, L. C. (2017) ‘Oxidative stress in pre-eclampsia; have we been looking in the wrong place?’, Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 8, pp. 1-5. doi:10.1016/j.preghy.2017.01.004en
dc.identifier.doi10.1016/j.preghy.2017.01.004
dc.identifier.endpage5en
dc.identifier.issn2210-7789
dc.identifier.journaltitlePregnancy Hypertension: An International Journal of Women's Cardiovascular Healthen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/5202
dc.identifier.volume8en
dc.language.isoenen
dc.publisherElsevier B.V.en
dc.rights© 2017, International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectPre-eclampsiaen
dc.subjectOxidative stressen
dc.titleOxidative stress in pre-eclampsia; have we been looking in the wrong place?en
dc.typeArticle (peer-reviewed)en
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