Molecular epidemiology of sexually transmitted human papillomavirus in a self referred group of women in Ireland

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dc.contributor.authorMenton, John F.
dc.contributor.authorCremin, Suzanne M.
dc.contributor.authorCanier, Lydie
dc.contributor.authorHorgan, Mary
dc.contributor.authorFanning, Liam J.
dc.date.accessioned2016-06-17T13:23:34Z
dc.date.available2016-06-17T13:23:34Z
dc.date.issued2009-07-23
dc.date.updated2013-01-18T15:04:32Z
dc.description.abstractBackground: Human papillomavirus (HPV) causes cervical cancer and external genital warts. The purpose of this study is to document the genotype distribution of HPV in females aged between 18 and 34 who self-referred to an STI clinic with visible external genital warts (EGW). Scrapings were taken from visible external genital warts (EGW). These scrapings were analysed by PCR for the presence of HPV DNA. Positive samples were then genotyped by means of a commercially available assay (LiPA). A comparison of genotyping results determined by the LiPA assay and direct amplicon DNA sequencing was also performed. Results: Ninety-two patients out of 105 samples (88%) had detectable levels of HPV DNA. The majority of individuals with EGW (66%) showed the presence of two or more genotypes. The most common HPV genotypes present in the study population were HPV-6, HPV-11, HPV-16, HPV-18, HPV-33 and HPV-53. Potential effects of vaccination on HPV molecular epidemiology indicate that 40% of the patients could have been protected from the high risk genotypes HPV-16 and HPV-18.Conclusion: This is the first report of the molecular epidemiology of external genital warts in women aged between 18 and 34 from Ireland based on results from a LiPA assay. The study shows that most individuals are infected with multiple genotypes including those with high oncogenic potential and that the newly available HPV vaccines could have a significant impact on prevalence of the most common HPV genotypes in this study population.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid112
dc.identifier.citationMenton, J. F., Cremin, S. M. ,Canier, L., Horgan, M. and Fanning, L. J. (2009) 'Molecular epidemiology of sexually transmitted human papillomavirus in a self referred group of women in Ireland'. Virology Journal, 6 . http://dx.doi.org/10.1186/1743-422X-6-112en
dc.identifier.doi10.1186/1743-422X-6-112
dc.identifier.endpage6en
dc.identifier.issn1743-422X
dc.identifier.journaltitleVirology Journalen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/2754
dc.identifier.volume6en
dc.language.isoenen
dc.publisherBiomed Centralen
dc.rights© 2009 Menton et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/en
dc.subjectCervical canceren
dc.subjectParticle vaccineen
dc.subjectGenital wartsen
dc.subjectClassificationen
dc.subjectHPVen
dc.subjectEfficacyen
dc.subjectType-18en
dc.subjectLesionsen
dc.subjectHuman papillomavirusen
dc.titleMolecular epidemiology of sexually transmitted human papillomavirus in a self referred group of women in Irelanden
dc.typeArticle (peer-reviewed)en
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