Comparing the diagnostic accuracy of two cognitive screening instruments in different dementia subtypes and clinical depression

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dc.contributor.authorO'Caoimh, Rónán
dc.contributor.authorMolloy, D. William
dc.date.accessioned2019-10-01T10:38:07Z
dc.date.available2019-10-01T10:38:07Z
dc.date.issued2019-07-08
dc.description.abstractShort but accurate cognitive screening instruments are required in busy clinical practice. Although widely-used, the diagnostic accuracy of the standardised Mini-Mental State Examination (SMMSE) in different dementia subtypes remains poorly characterised. We compared the SMMSE to the Quick Mild Cognitive Impairment (Qmci) screen in patients (n = 3020) pooled from three memory clinic databases in Canada including those with mild cognitive impairment (MCI) and Alzheimer’s, vascular, mixed, frontotemporal, Lewy Body and Parkinson’s dementia, with and without co-morbid depression. Caregivers (n = 875) without cognitive symptoms were included as normal controls. The median age of patients was 77 (Interquartile = ±9) years. Both instruments accurately differentiated cognitive impairment (MCI or dementia) from controls. The SMMSE most accurately differentiated Alzheimer’s (AUC 0.94) and Lewy Body dementia (AUC 0.94) and least accurately identified MCI (AUC 0.73), vascular (AUC 0.74), and Parkinson’s dementia (AUC 0.81). The Qmci had statistically similar or greater accuracy in distinguishing all dementia subtypes but particularly MCI (AUC 0.85). Co-morbid depression affected accuracy in those with MCI. The SMMSE and Qmci have good-excellent accuracy in established dementia. The SMMSE is less suitable in MCI, vascular and Parkinson’s dementia, where alternatives including the Qmci screen may be used. The influence of co-morbid depression on scores merits further investigation.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid93en
dc.identifier.citationO’Caoimh, R. and Molloy, D. W. (2019) 'Comparing the Diagnostic Accuracy of Two Cognitive Screening Instruments in Different Dementia Subtypes and Clinical Depression', Diagnostics, 9(3), 93 (17pp). DOI: 10.3390/diagnostics9030093en
dc.identifier.doi10.3390/diagnostics9030093en
dc.identifier.eissn2075-4418
dc.identifier.endpage17en
dc.identifier.issued3en
dc.identifier.journaltitleDiagnosticsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8653
dc.identifier.volume9en
dc.language.isoenen
dc.publisherMDPIen
dc.relation.urihttps://www.mdpi.com/2075-4418/9/3/93/htm
dc.rights© The Author(s) 2019. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citeden
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectDementiaen
dc.subjectMild cognitive impairmenten
dc.subjectScreeningen
dc.subjectAccuracyen
dc.subjectStandardised mini-mental state examinationen
dc.subjectQuick mild cognitive impairment screenen
dc.titleComparing the diagnostic accuracy of two cognitive screening instruments in different dementia subtypes and clinical depressionen
dc.typeArticle (peer-reviewed)en
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