Divergent and convergent evolution after a common-source outbreak of hepatitis C virus.

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dc.contributor.authorRay, Stuart C.
dc.contributor.authorFanning, Liam J.
dc.contributor.authorWang, Xiao-Hong
dc.contributor.authorNetski, Dale M.
dc.contributor.authorKenny-Walsh, Elizabeth
dc.contributor.authorThomas, David L.
dc.contributor.funderHealth Research Boarden
dc.date.accessioned2013-01-29T10:20:45Z
dc.date.available2013-01-29T10:20:45Z
dc.date.copyright2005
dc.date.issued2005-06
dc.date.updated2013-01-21T12:59:14Z
dc.description.abstractThe genomic sequences of viruses that are highly mutable and cause chronic infection tend to diverge over time. We report that these changes represent both immune-driven selection and, in the absence of immune pressure, reversion toward an ancestral consensus. Sequence changes in hepatitis C virus (HCV) structural and nonstructural genes were studied in a cohort of women accidentally infected with HCV in a rare common-source outbreak. We compared sequences present in serum obtained 18–22 yr after infection to sequences present in the shared inoculum and found that HCV evolved along a distinct path in each woman. Amino acid substitutions in known epitopes were directed away from consensus in persons having the HLA allele associated with that epitope (immune selection), and toward consensus in those lacking the allele (reversion). These data suggest that vaccines for genetically diverse viruses may be more effective if they represent consensus sequence, rather than a human isolate.en
dc.description.sponsorshipNational Institutes of Health grants U19 AI40035 and R01 DA016078, and Irish Health Research Board grant HC08/97.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationRay SC, Fanning L, Wang XH, Netski DM, Kenny-Walsh E, Thomas DL (2005) 'Divergent and convergent evolution after a common-source outbreak of hepatitis C virus'. The Journal of experimental medicine, 201 (11):1753-1759. doi: 10.1084/jem.20050122en
dc.identifier.doi10.1084/jem.20050122
dc.identifier.endpage1759en
dc.identifier.issued11en
dc.identifier.journaltitleThe Journal of experimental medicineen
dc.identifier.startpage1753en
dc.identifier.urihttps://hdl.handle.net/10468/936
dc.identifier.volume201en
dc.language.isoenen
dc.publisher© 2005 Rockefeller University Pressen
dc.rights© 2005 Rockefeller University Press. Beginning six months after publication, RUP grants the public the nonexclusive right to copy, distribute, or display the Work under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en
dc.subjectVirusen
dc.subjectHepatitis Cen
dc.subjectDivergent evolutionen
dc.subjectConvergent evolutionen
dc.subjectGenomic sequenceen
dc.subjectVaccineen
dc.subjectWomenen
dc.subjectOutbreaken
dc.subject.lcshHepatitis C--Treatmenten
dc.titleDivergent and convergent evolution after a common-source outbreak of hepatitis C virus.en
dc.typeArticle (peer-reviewed)en
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