Bifidobacterium bifidum PRL2010 alleviates intestinal ischemia/reperfusion injury

Simple item page
dc.contributor.authorDuranti, Sabrina
dc.contributor.authorVivo, Valentina
dc.contributor.authorZini, Irene
dc.contributor.authorMilani, Christian
dc.contributor.authorMangifesta, Marta
dc.contributor.authorAnzalone, Rosaria
dc.contributor.authorMancabelli, Leonardo
dc.contributor.authorViappiani, Alice
dc.contributor.authorCantoni, Anna Maria
dc.contributor.authorBarocelli, Elisabetta
dc.contributor.authorvan Sinderen, Douwe
dc.contributor.authorBertoni, Simona
dc.contributor.authorTurroni, Francesca
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderGenProbio srlen
dc.date.accessioned2019-10-28T07:05:07Z
dc.date.available2019-10-28T07:05:07Z
dc.date.issued2018-08-30
dc.description.abstractMesenteric ischemia/reperfusion is a clinical emergency with high morbidity and mortality due to the transient reduction of blood supply to the bowel. In recent years, the critical contribution of gut microbiome to human health and proper gastrointestinal functions has gradually emerged. In the current study, we investigated the protective effects of five days supplementation with Bifidobacterium bifidum PRL2010 in a murine model of gut ischemia/reperfusion. Our findings indicate that animals pretreated with B. bifidum PRL2010 showed lower neutrophil recruitment in the lungs, remarkably reduced bacterial translocation and decreased transcription levels of TNFalpha and IL-10 both in liver and kidneys, at the same time increasing those of IL-12 in kidneys. Inhibiting the adhesion of pathogenic bacteria and boosting host innate immunity responses are among the possible protective mechanisms enacted by the probiotic. These results demonstrate that short-period treatment with B. bifidum PRL2010 is a potential strategy to dampen remote organ injury due to mesenteric ischemia/reperfusion.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide0202670en
dc.identifier.citationDuranti, S., Vivo, V., Zini, I., Milani, C., Mangifesta, M., Anzalone, R., Mancabelli, L., Viappiani, A., Cantoni, A.M., Barocelli, E. and van Sinderen, D., 2018. Bifidobacterium bifidum PRL2010 alleviates intestinal ischemia/reperfusion injury. PloS one, 13(8), e0202670, (16 pp.). DOI:10.1371/journal.pone.0202670en
dc.identifier.doi10.1371/journal.pone.0202670en
dc.identifier.eissn1932-6203
dc.identifier.endpage16en
dc.identifier.issued8en
dc.identifier.journaltitlePLoS ONEen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8890
dc.identifier.volume13en
dc.language.isoenen
dc.publisherPLoSen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202670
dc.rights© 2018 Duranti et al. GenProbio This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectIntestinal ischemia/reperfusion injuryen
dc.subjectGut microbiomeen
dc.subjectBifidobacterium bifidum PRL2010en
dc.subjectHuman healthen
dc.titleBifidobacterium bifidum PRL2010 alleviates intestinal ischemia/reperfusion injuryen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
journal.pone.0202670.pdf
Size:
17.02 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download
Thumbnail Image
Name:
pone.0202670.s001.tiff
Size:
2.2 MB
Format:
Tag Image File Format
Description:
Supplementary file 1
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Microbiology - Journal Articles
APC Microbiome Ireland - Journal Articles