Genome-scale analyses of health-promoting bacteria: probiogenomics

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dc.contributor.authorVentura, Marco
dc.contributor.authorO'Flaherty, Sarah
dc.contributor.authorClaesson, Marcus J.
dc.contributor.authorTurroni, Francesca
dc.contributor.authorKlaenhammer, Todd R.
dc.contributor.authorvan Sinderen, Douwe
dc.contributor.authorO'Toole, Paul W.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHealth Research Boarden
dc.contributor.funderParmalat SpA, Italy
dc.contributor.funderDepartment of Agriculture and Food, Irelanden
dc.contributor.funderMinistero dell’Istruzione, dell’Università e della Ricerca, Italyit
dc.contributor.funderEuropean Commissionen
dc.date.accessioned2010-02-16T10:44:14Z
dc.date.available2010-02-16T10:44:14Z
dc.date.issued2009-01
dc.description.abstractThe human body is colonized by an enormous population of bacteria (microbiota) that provides the host with coding capacity and metabolic activities. Among the human gut microbiota are health-promoting indigenous species (probiotic bacteria) that are commonly consumed as live dietary supplements. Recent genomics-based studies (probiogenomics) are starting to provide insights into how probiotic bacteria sense and adapt to the gastrointestinal tract environment. In this Review, we discuss the application of probiogenomics in the elucidation of the molecular basis of probiosis using the well-recognized model probiotic bacteria genera Bifidobacterium and Lactobacillus as examples.en
dc.description.sponsorshipScience Foundation Ireland (CSET); Department of Agriculture and Food, Ireland; Health Research Board (FHRI award); Ministero dell’Istruzione, dell’Università e della Ricerca, Italy (Italian Award for Outstanding Young Researcher scheme "Incentivazione alla mobilità di studiosi stranieri e italiani residente all’estero" 2005-2009); European Commission (Marie Curie Reintegration Grant MERG-CT-2005-03080); Parmalat SpA, Italyen
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdf
dc.identifier.citationVentura M., O'Flaherty S., Claesson M. J., Turroni F., Klaenhammer T.R., van Sinderen D., O'Toole P.W. 2009. Genome-scale analyses of health-promoting bacteria: probiogenomics. Nature Reviews Microbiology 7, pp61-71 doi:10.1038/nrmicro2047en
dc.identifier.doi10.1038/nrmicro2047
dc.identifier.endpage71en
dc.identifier.issn1740-1526
dc.identifier.issn1740-1534
dc.identifier.issued1en
dc.identifier.journaltitleNature Reviews. Microbiologyen
dc.identifier.startpage61en
dc.identifier.urihttps://hdl.handle.net/10468/118
dc.identifier.volume7en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.rights© 2009 Macmillan Publishers Limited. All rights reserveden
dc.rights.urihttp://www.nature.com/authors/editorial_policies/license.htmlen
dc.subjectGenomicsen
dc.subjectFunctional genomicsen
dc.subjectMicrobiotaen
dc.subjectIntestinal tracten
dc.subjectProbiotic bacteriaen
dc.subject.lcshBifidobacterium -- Genomicsen
dc.subject.lcshLactobacillus -- Genomicsen
dc.titleGenome-scale analyses of health-promoting bacteria: probiogenomicsen
dc.typeArticle (peer-reviewed)en
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