Detection and prevention of adverse drug reactions in multi-morbid older patients

dc.check.date2019-09-12
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorJennings. Emma L. M.
dc.contributor.authorGallagher, Paul F.
dc.contributor.authorO'Mahony, Denis
dc.date.accessioned2019-02-12T11:55:43Z
dc.date.available2019-02-12T11:55:43Z
dc.date.issued2018-09-12
dc.date.updated2019-02-12T11:38:48Z
dc.description.abstractAdverse drug reactions (ADRs) are a recognised unintentional form of iatrogenic harm, which commonly occur in older adults who have high levels of multi-morbidity and associated polypharmacy. Previous studies estimate that at least one in 10 hospitalised older patients will experience an ADR. While recent research indicates that this could be as high as 39% in hospitalised multi-morbid, older adults, up to two-thirds of these ADRs can be considered preventable and therefore potentially avoidable. In addition to increasing patient morbidity and contributing to avoidable mortality, there is an associated cost implication with ADR occurrence. This commentary summarises current mainstream research in terms of ADR detection, prediction and prevention in multi-morbid older patients. At present, the biggest barrier to understanding and comparing ADRs in the literature is the large heterogeneity that exists in the population and study methods. Furthermore, there is the lack of standardised universally accepted methodology for ADR prediction, detection, causality assessment and subsequent prevention in older people. Standard available methods of ADR prediction applied to a heterogeneous multi-morbid population are generally unsatisfactory. Without an instrument that consistently and reliably predicts ADR risk in a reproducible manner, ADR prevention in multi-morbid older patients is challenging. Further attention should be focused on the culprit drugs that commonly lead to major ADRs in older multi-morbid hospitalised patients with polypharmacy. Risk associated with particular drug classes may possibly predict ADR occurrence better than patient characteristics alone. Current research is examining this drug class focus for ADR prevention in multi-morbid older people.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationJennings, E., Gallagher, P. and O'Mahony, D. (2018) 'Detection and prevention of adverse drug reactions in multi-morbid older patients', Age and Ageing, 48(1), pp. 10-13. doi: 10.1093/ageing/afy157en
dc.identifier.doi10.1093/ageing/afy157
dc.identifier.endpage13en
dc.identifier.issn0002-0729
dc.identifier.issn1468-2834
dc.identifier.issued1en
dc.identifier.journaltitleAge and Ageingen
dc.identifier.startpage10en
dc.identifier.urihttps://hdl.handle.net/10468/7480
dc.identifier.volume48en
dc.language.isoenen
dc.publisherOxford University Press on behalf of the British Geriatrics Societyen
dc.rights© 2018, the Authors. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. This is a pre-copyedited, author-produced PDF of an article accepted for publication in Age and Ageing following peer review. The version of record is available online at: https://doi.org/10.1093/ageing/afy157en
dc.subjectAdverse drug reactionen
dc.subjectPreventionen
dc.subjectPredictionen
dc.subjectPolypharmacyen
dc.subjectOlder peopleen
dc.titleDetection and prevention of adverse drug reactions in multi-morbid older patientsen
dc.typeArticle (peer-reviewed)en
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