A simple synthesis of polymer coated gold and silver nanoparticles in water for potential use in biomedical applications

Simple item page
dc.contributor.authorRahme, Kamil
dc.contributor.authorMinassian, G.
dc.contributor.authorGhanem, Esther.
dc.contributor.authorNakhl, Michel
dc.contributor.authorEl Hage, Rolan
dc.contributor.authorSouaid, Eddy
dc.contributor.authorHolmes, Justin D.
dc.contributor.funderNational Council for Scientific Researchen
dc.date.accessioned2019-12-05T10:09:55Z
dc.date.available2019-12-05T10:09:55Z
dc.date.issued2018-05
dc.date.updated2019-12-05T10:01:53Z
dc.description.abstractIn this study Silver (Ag) and Gold (Au) nanoparticles (NPs) of different surface charges (positively charged, negatively charged, or nearly neutral) and sizes were obtained using ascorbic acid as a reducing agent and multiple polymers such as Chitosan (Chit), Poly-L-Lysine (PLL), Polyvinyl alcohol (PVA), Polyethylene glycol (PEG) or sodium citrate as stabilizing ligands. The obtained NPs were characterized using UV-visible spectroscopy (UV-vis), Dynamic Light Scattering (DLS), and Zeta Potential (Q measurements. On the other hand, AuNPs with different coating (PLL, PVA and PEG) and charges were tested on whole human blood samples, specifically on neutrophils using a Neutrophil Function Test (NFT). Our results demonstrated that AuNPs-PVA with a slight negative charge (C = -15 mV) and PEgylated AuNPs-PLL (AuNPs-PLL-PEG) with a slight positive charge (ζ = + 9 mV) were found to be the least detected by neutrophils making them suitable for biomedical applications.en
dc.description.sponsorshipNational Council for Scientific Research Lebanon (CNRS-L-GRP2015-3538)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationRahme, K., Minassian, G., Ghanem, E., Nakhl, M., El Hage, R., Souaid, E. and Holmes, J. D. (2018) 'A simple synthesis of polymer coated gold and silver nanoparticles in water for potential use in biomedical applications', 11th Annual TechConnect World Innovation Conference and Expo, Anaheim, CA. USA, 13-16 May, TechConnect Briefs, pp. 87-90. isbn: 978-0-9975117-8-9en
dc.identifier.endpage90en
dc.identifier.isbn978-0-9975117-8-9
dc.identifier.startpage87en
dc.identifier.urihttps://hdl.handle.net/10468/9334
dc.language.isoenen
dc.publisherTechConnecten
dc.relation.urihttps://briefs.techconnect.org/papers/a-simple-synthesis-of-polymer-coated-gold-and-silver-nanoparticles-in-water-for-potential-use-in-biomedical-applications/
dc.rights© 2018 TechConnect. All rights reserved.en
dc.subjectCanceren
dc.subjectCytotoxixityen
dc.subjectNanoparticlesen
dc.subjectNeutrophilsen
dc.subjectPolymersen
dc.subjectAmino acidsen
dc.subjectAscorbic aciden
dc.subjectDynamic light scatteringen
dc.subjectFunctional polymersen
dc.subjectGold coatingsen
dc.subjectMedical applicationsen
dc.subjectPhase locked loopsen
dc.subjectPlastic coatingsen
dc.subjectPolyethylenesen
dc.subjectSodium compoundsen
dc.subjectSynthesis (chemical)en
dc.subjectUltraviolet visible spectroscopyen
dc.subjectBiomedical applicationsen
dc.subjectGold and silver nanoparticlesen
dc.subjectNeutrophil functionsen
dc.subjectPoly (vinyl alcohol) (PVA)en
dc.subjectUV-visible spectroscopyen
dc.subjectSilver nanoparticlesen
dc.titleA simple synthesis of polymer coated gold and silver nanoparticles in water for potential use in biomedical applicationsen
dc.typeConference itemen
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
6688.pdf
Size:
847.52 KB
Format:
Adobe Portable Document Format
Description:
Published version
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Chemistry - Conference Items
Tyndall National Institute - Conference Items