Higher prevalence of unrecognized kidney disease at high altitude

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Hurtado-Arestegui, Abdias
Plata-Cornejo, Raul
Cornejo, Arturo
Mas, Guiliana
Carbajal, Luz
Sharma, Shailendra
Swenson, Erik R.
Johnson, Richard J.
Pando, Jackelina
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Springer International Publishing AG on behalf of the Italian Society of Nephrology
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Background: High altitude renal syndrome has been described in populations with excessive erythrocytosis. We evaluated whether high altitude (HA) dwellers might be at increased risk for kidney disease. Methods: We performed a cross-sectional study to investigate differences in prevalence of kidney function and metabolic syndrome in healthy subjects living at HA vs. sea level (SL) without any known history of hypertension, diabetes or chronic kidney disease. Results: We examined 293 subjects, aged 40 to 60 years: 125 SL (154 m) and 168 HA (3640 m) dwellers. HA dwellers had higher serum creatinine, lower estimated glomerular function rate (eGFR) (69.5 ± 15.2 vs. 102.1 ± 17.8 ml/min/1.73 m2, p < 0.0001), more proteinuria and higher hemoglobin concentrations compared to SL subjects. HA subjects had a lower prevalence of metabolic syndrome. Hemoglobin concentrations correlated inversely with eGFR in female (p = 0.001) and male (p = 0.03) HA dwellers. Using logistic regression analysis to compare subjects with eGFR < 90 vs. > 90 ml/min/1.73 m2, a lower eGFR was associated with female gender (odds ratio adjusted: 5.65 [95% confidence interval: 2.43–13.13]; p = 0.001), high altitude (14.78 [6.46–33.79]; p = 0.001), hemoglobin (1.68 [1.16–2.43]; p = 0.001) and uric acid (1.93 [1.36–2.72]; p = 0.001). Conclusions: Dwellers at high altitude who are considered healthy have worse kidney function, a higher prevalence of proteinuria and a lower prevalence of metabolic syndrome compared to people living at SL.
Cardiovascular risk , High altitude , Kidney function , Proteinuria
Hurtado-Arestegui, A., Plata-Cornejo, R., Cornejo, A., Mas, G., Carbajal, L., Sharma, S., Swenson, E. R., Johnson, R. J. and Pando, J. (2017) 'Higher prevalence of unrecognized kidney disease at high altitude', Journal of Nephrology, 31, pp. 263-269. doi:10.1007/s40620-017-0456-0
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© 2017, Italian Society of Nephrology. Published by Springer International Publishing AG. This is a post-peer-review, pre-copyedit version of an article published in Journal of Nephrology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s40620-017-0456-0